4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, (2S-(2alpha,5alpha,6beta(R*)))- | 74591-00-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, (2S-(2alpha,5alpha,6beta(R*)))-
• 英文别名: sodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-[(4-oxo-1H-1,5-naphthyridine-3-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• CAS: 74591-00-7
• 化学式: C25H22N5NaO6S
• 分子量: 543.5
• InChiKey: DIGBQDMXLUJMHN-TVXOXULGSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  186
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Dimethyl sulfoxide adducts of sodium 6-(D(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido)phenylacetamido)penicillanate or the derivative thereof bearing a hydroxyl group at the p-position of the phenyl group, methods for their preparation and decomposition, and their use as intermediates for purifying the crude penicillins
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0006688A1

  公开（公告）日：1980-01-09

  Sodium 6- D (―)[-α-(4-hydroxy-1,5-naphtthydridine-3-carboxyamido) phenylacetamido] penicillanate or the derivative thereof bearing alydroxylgroup at the p-position of the phenyl group in a crude state can be purified efficiently through the reaction with dimethyl-sulfoxide in a liquid medium and decomposition of the obtained adducts in a water-containing liquid medium.

  6- D (-)[-α-(4-羟基-1,5-萘啶-3-羧酰胺基)苯乙酰胺基]青霉烷酸钠或其衍生物在粗制状态下在苯基的 p 位上带有lydroxylgroup，可以通过在液体介质中与二甲基亚砜反应，并在含水液体介质中分解所得到的加合物来有效提纯。
• US4244870A
  申请人：——

  公开号：US4244870A

  公开（公告）日：1981-01-13
• US4226769A
  申请人：——

  公开号：US4226769A

  公开（公告）日：1980-10-07