3-amino-8-(2,3-difluoro-phenyl)-5-methyl-octanoic acid | 610300-27-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-amino-8-(2,3-difluoro-phenyl)-5-methyl-octanoic acid
• 英文别名: 3-Amino-8-(2,3-difluorophenyl)-5-methyloctanoic acid
• CAS: 610300-27-1
• 化学式: C₁₅H₂₁F₂NO₂
• 分子量: 285.334
• InChiKey: FRXVVOBOAUAOCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Amino acids with affinity for the alpha-2-delta-protein
  申请人：——

  公开号：US20030195251A1

  公开（公告）日：2003-10-16

  This invention relates to certain &bgr;-amino acids that bind to the alpha-2-delta (&agr;2&dgr;) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  这项发明涉及与钙通道的α-2-δ（α2δ）亚基结合的某些β-氨基酸。这些化合物及其药用盐在治疗各种精神疾病、疼痛和其他疾病方面具有用处。
• Methods for using amino acids with affinity for the alpha2delta-protein
  申请人：Bramson Candace

  公开号：US20050124669A1

  公开（公告）日：2005-06-09

  This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  本发明涉及一些与钙通道的α2δ亚单位结合的β-氨基酸。这些化合物及其药学上可接受的盐在治疗各种精神疾病、疼痛和其他疾病方面是有用的。
• Amino acids with affinity for the alpha2delta-protein
  申请人：Barta Nancy Sue

  公开号：US20050272783A1

  公开（公告）日：2005-12-08

  This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric pain and other disorders.

  本发明涉及一些能够与钙通道的α2δ亚单位结合的β-氨基酸。这些化合物及其药学上可接受的盐在治疗各种精神疼痛和其他疾病方面非常有用。
• Amino acids with affinity for the alpha-2-delta protein
  申请人：Warner-Lambert Company LLC

  公开号：EP1614675A2

  公开（公告）日：2006-01-11

  The invention relates to compounds of the formula II, III and IV, compositions comprising them and their use in the treatment of, inter alia, pain.

  本发明涉及式 II、III 和 IV 的化合物、包含这些化合物的组合物以及它们在治疗疼痛等方面的用途。
• Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
  申请人：Coe W. Jotham

  公开号：US20050043406A1

  公开（公告）日：2005-02-24

  Pharmaceutical compositions are disclosed for the treatment of obesity, an overweight condition and compulsive overeating. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotinic receptor partial agonist and an alpha2dela ligand and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.

  本发明公开了用于治疗肥胖、超重和强迫性暴饮暴食的药物组合物。这些药物组合物由烟碱受体部分激动剂和 alpha2dela 配体的治疗有效组合物以及药学上可接受的载体组成。还公开了使用这些化合物的方法。