3-hydroxy-pyrene-1-sulfonic acid | 861200-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 3-hydroxy-pyrene-1-sulfonic acid
• 英文别名: 3-Hydroxy-pyren-1-sulfonsaeure；3-Hydroxypyrene-1-sulfonic acid
• CAS: 861200-01-3
• 化学式: C₁₆H₁₀O₄S
• 分子量: 298.319
• InChiKey: WVTZIZZGEZGCPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-hydroxy-pyrene-1-sulfonic acid 、 sodium acetate 、 乙酸酐 反应 2.0h， 以75%的产率得到sodium 3-acetoxypyrene-1-sulfonate
  参考文献：
  名称：

  [EN] HPTS-MONO AND BIS CYS-MA POLYMERIZABLE FLUORESCENT DYES FOR USE IN ANALYTE SENSORS
  [FR] COLORANTS FLUORESCENTS HPTS MONOSUBSTITUÉS ET BISUSBTITUÉS CYS-MA POUR UNE UTILISATION DANS DES DÉTECTEURS ANALYTIQUES

  摘要：

  揭示了用于分析物检测的新型荧光染料。具体地，提供了单取代和双取代的HPTS染料以及制备方法。

  公开号：

  WO2009021057A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 3-hydroxy-pyrene-1-sulfonic acid
  参考文献：
  名称：

  Tietze; Bayer, Justus Liebigs Annalen der Chemie, 1939, vol. 540, p. 189,192,202,203,204

  摘要：

  DOI：

文献信息

• HPTS-MONO AND BIS CYS-MA POLYMERIZABLE FLUORESCENT DYES FOR USE IN ANALYTE SENSORS
  申请人：SURI JEFF T.

  公开号：US20090061528A1

  公开（公告）日：2009-03-05

  Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.

  本发明揭示了用于分析物检测的新型荧光染料。具体来说，提供了单取代和双取代的HPTS染料及其制备方法。
• Bioreactor and bioprocessing technique
  申请人：University of Maryland, Baltimore County

  公开号：EP2371942A2

  公开（公告）日：2011-10-05

  The invention bioprocessing system and technique relies on non-invasive optical chemical sensing technology wherein an optical excitation source excites an optical chemical sensor. The optical chemical sensor then emits luminescence or absorbs light which is measured by a detector. The luminescence emitted from the chemical sensor or the amount of light absorbed by the chemical sensor is related to the concentration of an analyte, such as oxygen. If the luminescence emitted changes, or if the amount of light absorbed changes, then the concentration of the analyte has changed. Using such a system to measure and adjust multiple parameters at one time allows one to efficiently and cost-effectively determine optimal conditions for a given cell type and/or cell environment. By combining cell cultivation with optical chemical sensing technology, cultivation can be successfully and rapidly performed, controlled and monitored in small volumes in an automated, parallel fashion at less expense than current bioprocess techniques. Figure (1) is a schematic diagram of a high throughput microbioprocessing system in accordance with one embodiment of the present invention.

  本发明的生物处理系统和技术依赖于非侵入式光学化学传感技术，其中光学激发源激发光学化学传感器。然后，光学化学传感器发出荧光或吸收光，并由检测器进行测量。化学传感器发出的荧光或吸收的光量与氧气等分析物的浓度有关。如果发出的荧光或吸收的光量发生变化，则说明分析物的浓度发生了变化。使用这种系统一次性测量和调整多个参数，可以高效、经济地确定特定细胞类型和/或细胞环境的最佳条件。通过将细胞培养与光学化学传感技术相结合，可以成功、快速地以自动化、并行的方式对小容量细胞进行培养、控制和监测，而且成本低于当前的生物工艺技术。图（1）是根据本发明一个实施例的高通量微生物处理系统示意图。
• CELL CULTURE FLASKS, SENSOR INSERTS, AND SYSTEMS AND METHODS COMPRISING THE SAME
  申请人：Scientific Industries, Inc.

  公开号：EP3805357A2

  公开（公告）日：2021-04-14

  Embodiments disclosed herein relate to novel flasks, methods and systems employing said novel flasks, and sensors for use within said flasks and systems. In some embodiments, flasks and systems described herein are used to culture cells and/or detect changes in pH levels or dissolved oxygen and/or carbon dioxide levels in a cell culture sample resulting from the growth of living cells contained within a reaction vessel such as a flask. The devices may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells.

  本文公开的实施方案涉及新型烧瓶、使用所述新型烧瓶的方法和系统以及用于所述烧瓶和系统的传感器。在某些实施例中，本文所述烧瓶和系统用于培养细胞和/或检测细胞培养样品中的 pH 值或溶解氧和/或二氧化碳水平的变化，这些变化是由反应容器（如烧瓶）中所含活细胞的生长引起的。这些装置可用于检测反应容器中所含液体中由于活细胞生长而引起的 pH 值和溶解氧水平的变化。
• Apparatus for detecting pH and dissolved oxygen
  申请人：Scientific Industries, Inc.

  公开号：US10379047B2

  公开（公告）日：2019-08-13

  Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.

  本发明公开了一种细胞培养监测系统的实施方案，该系统可包括一个具有准直和过滤组件的装置，用于激发和检测来自反应容器内基质的荧光。该装置可用于检测反应容器中液体的 pH 值和溶解氧水平因活细胞生长而发生的变化。激发光束可以由合束器产生并准直，然后射入反应容器，从而入射到基质上，使基质发出荧光。一些实施方案包括使用预期的波长偏移和移位滤波器/镜，以提高功能性并减少设备组件的空间。
• BIOREACTOR AND BIOPROCESSING TECHNIQUE
  申请人：University of Maryland at Baltimore County

  公开号：EP1309719A1

  公开（公告）日：2003-05-14