((4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2-phenyl-[1,3]dioxan-4-yl)-acetic acid ethyl ester | 1101046-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: ((4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2-phenyl-[1,3]dioxan-4-yl)-acetic acid ethyl ester
• 英文别名: ethyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2-phenyl-1,3-dioxan-4-yl]acetate
• CAS: 1101046-38-1
• 化学式: C₄₂H₄₃FN₂O₅
• 分子量: 674.812
• InChiKey: QQXKDHHHWQHTBG-LOEWGRRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  50
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL PROCESS FOR THE SYNTHESIS OF 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE
  申请人：——

  公开号：US20020133026A1

  公开（公告）日：2002-09-19

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  描述了一种通过新型合成制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺的改进工艺，其中将甲基氰乙酸酯在八个或更少的步骤中转化为所需产品，以及在该过程中使用的其他有价值的中间体。
• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1eta-pyrrole-3-carboxylic acid phenylamide
  申请人：Butler Eugene Donald

  公开号：US20050239869A1

  公开（公告）日：2005-10-27

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  一种改进的制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯胺的方法被描述，其中甲基氰乙酸酯经过八次或更少的操作转化为所需的产物，以及在该过程中使用的其他有价值的中间体。
• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  申请人：——

  公开号：US20030195353A1

  公开（公告）日：2003-10-16

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  本发明描述了一种改进的工艺，用于通过新的合成方法制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，其中甲基氰乙酸酯通过八个或更少的操作转化为所需的产物，以及用于该过程的其他有价值的中间体。
• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  申请人：Butler Eugene Donald

  公开号：US20070032664A1

  公开（公告）日：2007-02-08

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  描述了一种改进的方法，通过新合成法制备5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢-吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，其中甲基氰乙酸酯在八步或更少的操作中转化为所需的产物，以及在该过程中使用的其他有价值的中间体。
• Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrole-3-carboxylic acid and phenylamide
  申请人：Butler Eugene Donald

  公开号：US20070032662A1

  公开（公告）日：2007-02-08

  An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

  本文描述了一种改进的工艺，通过一种新的合成方法，将甲基氰乙酸酯转化为所需产物，即5-(4-氟苯基)-1-[2-((2R,4R)-4-羟基-6-氧代-四氢吡喃-2-基)-乙基]-2-异丙基-4-苯基-1H-吡咯烷-3-羧酸苯酰胺，该工艺仅需进行八次或更少的操作，同时还使用了其他有价值的中间体。