Fluphenazine decanoate dihydrochloride | 2376-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Fluphenazine decanoate dihydrochloride
• 英文别名: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate;dihydrochloride
• CAS: 2376-65-0
• 化学式: C32H46Cl2F3N3O2S
• 分子量: 664.7
• InChiKey: IJIYWOFSPALWMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.84
• 重原子数：
  43
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] SIGMA 1 RECEPTOR INHIBITION AS A NOVEL THERAPEUTICAL APPROACH AGAINST HEPATITIS C VIRUS INFECTION<br/>[FR] INHIBITION DU RÉCEPTEUR SIGMA 1 EN TANT QUE NOUVELLE APPROCHE THÉRAPEUTIQUE CONTRE UNE INFECTION PAR LE VIRUS DE L'HÉPATITE C
  申请人：GASTAMINZA PABLO

  公开号：WO2010101649A2

  公开（公告）日：2010-09-10

  A method for treating or ameliorating the symptoms of a Hepatitis C virus infection comprising administering a Sigma 1 receptor binding compound or an interfering RNA is provided. Methods for identifying a compound that inhibits a Hepatitis C virus infection are also provided. The Sigma 1 receptor binding compound or interfering RNA is believed to act by reducing the susceptibility of uninfected human cells to infection by Hepatitis C virus, inhibiting viral spread in a cellular population.