(+/-)-2,3-Dimethyl-2,3-diethyl-bernsteinsaeure | 91007-66-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+/-)-2,3-Dimethyl-2,3-diethyl-bernsteinsaeure
• 英文别名: meso-2,3-Dimethyl-2,3-diethyl-bernsteinsaeure；2,3-diethyl-2,3-dimethyl-succinic acid；2,3-Diaethyl-2,3-dimethyl-bernsteinsaeure；2,3-Diethyl-2,3-dimethylbutanedioic acid
• CAS: 91007-66-8
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: JFNNGXSYRGCBKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl-methyl-malonic acid monoethyl ester 在 硫酸 、 sodium 作用下， 生成 (+/-)-2,3-Dimethyl-2,3-diethyl-bernsteinsaeure
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110

文献信息

• MANUFACTURING METHOD OF SOLID CATALYST FOR PROPYLENE POLYMERIZATION
  申请人：Samsung Total Petrochemicals Co. Ltd.

  公开号：EP2511303A2

  公开（公告）日：2012-10-17

  Disclosed is a method for preparing a solid catalyst for propylene polymerization, specifically to a method for preparing a solid catalyst for propylene polymerization which can produce a polypropylene having high melt flow rate, a wide molecular distribution and excellent stereoregularity with a high production yield.

  本发明公开了一种丙烯聚合用固体催化剂的制备方法，特别是一种丙烯聚合用固体催化剂的制备方法，该方法可以生产出熔体流动速率高、分子分布广、立体规整性好、产量高的聚丙烯。
• Stefl, Zeitschrift fur Kristallographie, 1915, vol. 54, p. 359
  作者：Stefl

  DOI：——

  日期：——
• Dox, Journal of the American Chemical Society, 1925, vol. 47, p. 1475
  作者：Dox

  DOI：——

  日期：——
• Stefl, Diss.Techn.Hochsch.Muenchen <1914>,S.10
  作者：Stefl

  DOI：——

  日期：——
• Production of antibody catalysts
  申请人：IGEN, INC.

  公开号：EP0251093B1

  公开（公告）日：1994-08-17