methyl 1-(2-chlorophenyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate | 238428-19-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: methyl 1-(2-chlorophenyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate
• 英文别名: methyl (1S,3S)-1-(2-chlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
• CAS: 238428-19-8
• 化学式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.809
• InChiKey: YKRANILUQAWNOP-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-(2-chlorophenyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate 在 lithium aluminium tetrahydride 、 sulfur 作用下， 以 四氢呋喃 、 xylene 为溶剂， 生成 [1-(2-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl]methanol
  参考文献：
  名称：

  Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy1CDRI Communication No. 5795.1

  摘要：

  Substituted 9H-pyrido[3,4-b]indoles (beta-carbolines) identified in our laboratory as potential pharmacophore for designing macrofilaricidal agents, have been explored further for identifying the pharmacophore responsible for high order of adulticidal activity. This has led to syntheses and macrofilaricidal evaluations of a number of 1-aryl-9H-pyrido[3,4-b]indole-3-carboxyl derivatives (3-7). The macrofilarical activity was initially evaluated in vivo against Acanthoeilonema viteae. Amongst all the synthesized compounds, only twelve compounds namely 3a, 3c, 3d, 3f, 4c, 4d, 4f, 5a, 6f, 6h, 6i and 7h have exhibited either > 90% micro- or macrofilaricidal activity or sterilization of female worms. These compounds have also been screened against Litomosoides carinii and of these only 3f and 5a have also been found to be active. Finally these two compounds have been evaluated against Brugia malayi. The structure activity relationship (SAR) associated with position-1 and 3 substituents in beta-carbolines have been discussed. It has been observed that the presence of carbomethoxy at position-3 and an aryl substituent at position-1 in beta-carbolines effectively enhance antifilarial activity particularly against A. viteae. Amongst the various compounds screened, methyl 1-(4-methylphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (4c) has shown highest adulticidal activity and methyl 1-(4-chlorophenyl)1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate (3a) has shown highest microfilaricidal action against A. viteae at 50mg/ kgx5 days (ip). Another derivative of this compound namely 1-(4-chlorophenyl)-3-hydroxymethyl-9H-pyrido[3,4-b]indole (5a) exhibited highest activity against L. carinii at 30 mg/kg x 5 days (ip) and against B. malayi at 50 mg/kg x 5 days (ip) or at 200 mg/ kgx5 days (po). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00050-4
• 作为产物：
  描述：

  L-色氨酸 在 氯化亚砜 、 sodium carbonate 作用下， 以 甲醇 为溶剂， 生成 methyl 1-(2-chlorophenyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate
  参考文献：
  名称：

  Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy1CDRI Communication No. 5795.1

  摘要：

  Substituted 9H-pyrido[3,4-b]indoles (beta-carbolines) identified in our laboratory as potential pharmacophore for designing macrofilaricidal agents, have been explored further for identifying the pharmacophore responsible for high order of adulticidal activity. This has led to syntheses and macrofilaricidal evaluations of a number of 1-aryl-9H-pyrido[3,4-b]indole-3-carboxyl derivatives (3-7). The macrofilarical activity was initially evaluated in vivo against Acanthoeilonema viteae. Amongst all the synthesized compounds, only twelve compounds namely 3a, 3c, 3d, 3f, 4c, 4d, 4f, 5a, 6f, 6h, 6i and 7h have exhibited either > 90% micro- or macrofilaricidal activity or sterilization of female worms. These compounds have also been screened against Litomosoides carinii and of these only 3f and 5a have also been found to be active. Finally these two compounds have been evaluated against Brugia malayi. The structure activity relationship (SAR) associated with position-1 and 3 substituents in beta-carbolines have been discussed. It has been observed that the presence of carbomethoxy at position-3 and an aryl substituent at position-1 in beta-carbolines effectively enhance antifilarial activity particularly against A. viteae. Amongst the various compounds screened, methyl 1-(4-methylphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (4c) has shown highest adulticidal activity and methyl 1-(4-chlorophenyl)1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate (3a) has shown highest microfilaricidal action against A. viteae at 50mg/ kgx5 days (ip). Another derivative of this compound namely 1-(4-chlorophenyl)-3-hydroxymethyl-9H-pyrido[3,4-b]indole (5a) exhibited highest activity against L. carinii at 30 mg/kg x 5 days (ip) and against B. malayi at 50 mg/kg x 5 days (ip) or at 200 mg/ kgx5 days (po). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00050-4

文献信息

• Biological Studies and Target Engagement of the 2-<i>C</i>-Methyl-<scp>d</scp>-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1<i>R</i>,3<i>S</i>)-MMV008138 and Analogs
  作者：Maryam Ghavami、Emilio F. Merino、Zhong-Ke Yao、Rubayet Elahi、Morgan E. Simpson、Maria L. Fernández-Murga、Joshua H. Butler、Michael A. Casasanta、Priscilla M. Krai、Maxim M. Totrov、Daniel J. Slade、Paul R. Carlier、Maria Belen Cassera

  DOI：10.1021/acsinfecdis.7b00159

  日期：2018.4.13

  to gain insight into the structure–activity relationships by probing the ability of MMV008138 analogs to inhibit PfIspD recombinant enzyme. Here, we report PfIspD inhibition data for fosmidomycin (FOS) and 19 previously disclosed analogs and report parasite growth and PfIspD inhibition data for 27 new analogs of MMV008138. In addition, we show that MMV008138 does not target the recently characterized

  疟疾仍然是世界上最致命的疾病之一，耐药性寄生虫的出现一直是威胁。疟原虫寄生虫利用甲基赤藓糖醇磷酸酯（MEP）途径来合成异戊烯基焦磷酸酯（IPP）和二甲基烯丙基焦磷酸酯（DMAPP），这对于寄生虫的生长至关重要。以前，我们和其他人发现，疟疾框化合物MMV008138靶向于原生质体，并且该化合物对寄生虫的生长抑制作用可以通过补充IPP来逆转。进一步的工作表明，MMV008138靶向2- C-甲基-d酶。MEP途径中的-赤藓糖醇4-磷酸胞苷转移酶（IspD），可将MEP和胞苷三磷酸（CTP）转化为胞苷二磷酸甲基赤藓糖醇（CDP-ME）和焦磷酸。在这项工作中，我们试图通过探索MMV008138类似物抑制Pf IspD重组酶的能力来深入了解结构与活性之间的关系。这里，我们报告Pf的ISPD抑制数据用于膦胺霉素（FOS）和19个以前公开的类似物和报告寄生虫生长和Pf的ISPD抑制数据用于MMV0081
• Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria
  作者：Fernanda de Moura Alves、Jessica Correa Bezerra Bellei、Camila de Souza Barbosa、Caíque Lopes Duarte、Amanda Luisa da Fonseca、Ana Claudia de Souza Pinto、Felipe Oliveira Raimundo、Bárbara Albuquerque Carpinter、Ari Sérgio de Oliveira Lemos、Elaine Soares Coimbra、Alex Gutterres Taranto、Vinícius Novaes Rocha、Fernando de Pilla Varotti、Gustavo Henrique Ribeiro Viana、Kézia K. G. Scopel

  DOI：10.3390/pathogens11121529

  日期：——

  severe form of infection is caused by Plasmodium falciparum, which can lead to development of cerebral malaria (CM) and is responsible for deaths and significant neurocognitive sequelae throughout life. In this context and considering the emergence and spread of drug-resistant P. falciparum isolates, the search for new antimalarial candidates becomes urgent. β-carbolines alkaloids are good candidates since

  疟疾是一种流行于欠发达热带地区的传染病。最严重的感染形式是由恶性疟原虫引起的，它可导致脑型疟疾 (CM) 的发展，并导致死亡和一生中严重的神经认知后遗症。在这种情况下，考虑到耐药性恶性疟原虫分离株的出现和传播，寻找新的抗疟候选药物变得迫在眉睫。β-咔啉生物碱是很好的候选物，因为已报道这些化合物具有广泛的生物活性。在此，我们设计了 20 种化学实体，并针对恶性疟原虫分子靶标池（巴西疟疾分子靶标 (BRAMMT)）进行了计算机虚拟筛选。七个结构显示出与 PfFNR、PfPK7、PfGrx1 和 PfATP6 相互作用的潜力，正在合成并评估体外抗疟原虫活性。其中，化合物 3-6 和 10 在 µM 浓度下抑制 W2 菌株的生长，对人类细胞系具有低细胞毒性。发现计算机物理化学和药代动力学特性有利于口服给药。化合物 10 提供了针对 CM 的最佳结果，在感染后第 5 天的治疗性 (67.9%) 和抑制性
• [EN] COMPOSITIONS AND FORMULATIONS OF METHYLERTHRITOL PHOSPHATE PATHWAY INHIBITORS AND USES THEREOF<br/>[FR] COMPOSITIONS ET FORMULATIONS D'INHIBITEURS DE LA VOIE MÉTHYLERTHRITOL PHOSPHATE ET LEURS UTILISATIONS
  申请人：VIRGINIA TECH INTELL PROP

  公开号：WO2016069949A1

  公开（公告）日：2016-05-06

  Described herein are compounds and formulations thereof that can inhibit the methylerythritol phosphate pathway (MEP). Also described herein are methods of making and uses of the compounds and formulations thereof described herein.
• Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy1CDRI Communication No. 5795.1
  作者：Sanjay K. Srivastava、Alka Agarwal、Prem M.S. Chauhan、Shiv K. Agarwal、Amiya P. Bhaduri、Som N. Singh、Nigar Fatima、Ranjit K. Chatterjee

  DOI：10.1016/s0968-0896(99)00050-4

  日期：1999.6

  Substituted 9H-pyrido[3,4-b]indoles (beta-carbolines) identified in our laboratory as potential pharmacophore for designing macrofilaricidal agents, have been explored further for identifying the pharmacophore responsible for high order of adulticidal activity. This has led to syntheses and macrofilaricidal evaluations of a number of 1-aryl-9H-pyrido[3,4-b]indole-3-carboxyl derivatives (3-7). The macrofilarical activity was initially evaluated in vivo against Acanthoeilonema viteae. Amongst all the synthesized compounds, only twelve compounds namely 3a, 3c, 3d, 3f, 4c, 4d, 4f, 5a, 6f, 6h, 6i and 7h have exhibited either > 90% micro- or macrofilaricidal activity or sterilization of female worms. These compounds have also been screened against Litomosoides carinii and of these only 3f and 5a have also been found to be active. Finally these two compounds have been evaluated against Brugia malayi. The structure activity relationship (SAR) associated with position-1 and 3 substituents in beta-carbolines have been discussed. It has been observed that the presence of carbomethoxy at position-3 and an aryl substituent at position-1 in beta-carbolines effectively enhance antifilarial activity particularly against A. viteae. Amongst the various compounds screened, methyl 1-(4-methylphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (4c) has shown highest adulticidal activity and methyl 1-(4-chlorophenyl)1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate (3a) has shown highest microfilaricidal action against A. viteae at 50mg/ kgx5 days (ip). Another derivative of this compound namely 1-(4-chlorophenyl)-3-hydroxymethyl-9H-pyrido[3,4-b]indole (5a) exhibited highest activity against L. carinii at 30 mg/kg x 5 days (ip) and against B. malayi at 50 mg/kg x 5 days (ip) or at 200 mg/ kgx5 days (po). (C) 1999 Elsevier Science Ltd. All rights reserved.