1,4-双(3-甲氧基苯基)哌嗪 | 3367-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1,4-双(3-甲氧基苯基)哌嗪
• 英文名称: 1,4-bis(3-methoxyphenyl)piperazine
• CAS: 3367-50-8
• 化学式: C₁₈H₂₂N₂O₂
• 分子量: 298.385
• InChiKey: HFLWOTJAYCKLOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  N-methoxyethyl-3-methoxyaniline 、 2-苯氧基乙基氯乙酸酯 以11%的产率得到
  参考文献：
  名称：

  ABDUSALAMOV, A. B.;DUSTMUXAMEDOV, T. T.;ABDULLAEV, U.;ALLAYAROV, S. R., ZH. BCEC. XIM. O-BA, 1986, 31, N 1, 99-101

  摘要：

  DOI：

文献信息

• Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines
  作者：Eric Brenner、Raphaël Schneider、Yves Fort

  DOI：10.1016/s0040-4020(02)00750-0

  日期：2002.8

  synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.

  描述了使用与2,2'-联吡啶缔合的Ni（0）的催化剂组合，从相应的二胺和芳基氯化物选择性合成N-芳基或N，N'-二芳基哌嗪和三亚甲基（双）哌啶。Ni / 2，2'-联吡啶催化剂对于哌嗪的顺序芳基化也是有效的。报道了新型和不对称的1，4-二芳基哌嗪的制备。
• Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines
  作者：Shu-Hai Zhao、Aubry K. Miller、Jacob Berger、Lee A. Flippin

  DOI：10.1016/0040-4039(96)00877-5

  日期：1996.6

  A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.

  通过芳基卤化物与未保护的哌嗪的钯催化偶联反应，以中等至良好的产率合成了一系列芳基哌嗪。当使用2-甲基或2,6-二甲基哌嗪时，观察到非常高的区域选择性。
• Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N,N′-diarylation of piperazine
  作者：Eric Brenner、Raphaël Schneider、Yves Fort

  DOI：10.1016/s0040-4039(00)00277-x

  日期：2000.4

  The 2,2'-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a selective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N,N'-diaryl substituted piperazines is also described. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst
  作者：Masakazu Nishiyama、Toshihide Yamamoto、Yasuyuki Koie

  DOI：10.1016/s0040-4039(97)10659-1

  日期：1998.2

  A Pd/P(t-Bu)(3) catalyst system has revealed very high activity and selectivity for the amination of N-(hetero)aryl halides with unprotected piperazine. A wide variety of N-(hetero)arylpiperazines could be prepared using this catalyst. Turnover numbers up to 6400mol/mol have been obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.
• BISSEL E. R., J. HETEROCYCL. CHEM. <JHTC-AD>, 1977, 14, NO 3, 535-536
  作者：BISSEL E. R.

  DOI：——

  日期：——