苄氧羰基-赖氨酰-对硝基苯胺 | 70144-71-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苄氧羰基-赖氨酰-对硝基苯胺
• 英文名称: N(alpha)-Carbobenzoxylysine-4-nitroanilide
• 英文别名: benzyl N-[(2S)-6-amino-1-(4-nitroanilino)-1-oxohexan-2-yl]carbamate
• CAS: 70144-71-7
• 化学式: C20H24N4O5
• 分子量: 400.4
• InChiKey: FKFJWYPXPIUVGU-SFHVURJKSA-N

物化性质

• 沸点：
  670.8±55.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• ANTIGENIC COMPLEX FOR THE DIAGNOSIS AND TREATMENT OF PORPHYROMONAS GINGIVALIS INFECTION
  申请人：REYNOLDS ERIC CHARLES

  公开号：US20110081358A1

  公开（公告）日：2011-04-07

  The present invention provides a purified multimeric complex from P. gingivalis . The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.

  本发明提供了从牙龈炎梭菌中纯化的多聚复合物。该复合物包含来自RgpA、Kgp和HagA的至少一个结构域，分子量大约大于300千道尔顿。
• Antigenic Complex for the Diagnosis and Treatment of Porphyromonas Gingivalis Infection
  申请人：Reynolds Eric Charles

  公开号：US20090169568A1

  公开（公告）日：2009-07-02

  The present invention provides a purified multimeric complex form P. gingivalis . The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.

  本发明提供了一种纯化的P. gingivalis多聚复合物形式。该复合物包括来自RgpA、Kgp和HagA中至少一个域，并且分子量大约大于300 kDa。
• Synthetic peptide constructs for the diagnosis and treatment of periodontitus associated with porphyromonas gingivalis
  申请人：CSL Limited

  公开号：EP1985625A2

  公开（公告）日：2008-10-29

  The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease. The invention also relates to methods of treating or reducing the prospect of P. gingivalis infection.

  本发明涉及一种用于抑制与牙周病有关的口腔内牙龈卟啉单胞菌致病作用的口服组合物和免疫原性组合物。本发明还涉及治疗或减少牙龈卟啉单胞菌感染前景的方法。
• Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with porphyromonas gingivalis
  申请人：The University of Melbourne

  公开号：EP2246361A1

  公开（公告）日：2010-11-03

  The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease. The invention also relates to methods of treating or reducing the prospect of P. gingivalis infection.

  本发明涉及一种用于抑制与牙周病有关的口腔内牙龈卟啉单胞菌致病作用的口服组合物和免疫原性组合物。本发明还涉及治疗或减少牙龈卟啉单胞菌感染前景的方法。
• Diagnostics and treatments of periodontal disease
  申请人：The University of Melbourne

  公开号：US20030157637A1

  公开（公告）日：2003-08-21

  This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.

  本发明涉及牙龈卟啉单胞菌的 PrtR-PrtK 细胞表面蛋白。 牙龈卟啉单胞菌 特别是由 PrtR 和 PrtK 蛋白组成的多聚体细胞相关蛋白复合物。因此，本发明提供了一种基本纯化的抗原复合物，可用于提高针对牙龈卟啉单胞菌的抗体反应。 牙龈卟啉单胞菌的抗体反应。 该复合物包括至少一种由精氨酸特异性和赖氨酸特异性硫醇内肽酶组成的多聚体蛋白复合物，每种复合物都含有至少一个粘附素结构域，该复合物的分子量大于约 200 kDa。本发明还涉及基于所述复合物的药物组合物和相关制剂，用于检测、预防和治疗与牙龈脓疱病相关的牙周病。 牙龈脓疱病。