1-(2-mercaptoethyl)-3-phenylthiourea | 90562-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-mercaptoethyl)-3-phenylthiourea
• 英文别名: N-(2-Mercaptoaethyl)-N'-phenyl-thioharnstoff；1-Phenyl-3-(2-sulfanylethyl)thiourea
• CAS: 90562-71-3
• 化学式: C₉H₁₂N₂S₂
• 分子量: 212.34
• InChiKey: UNPXZTRFZYBIOH-UHFFFAOYSA-N

物化性质

• 沸点：
  325.5±44.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-mercaptoethyl)-3-phenylthiourea 在 sodium hydroxide 、 对甲苯磺酰氯 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 以76 mg的产率得到phenyl-(thiazolidin-2-ylidene)-amine hydrochloride
  参考文献：
  名称：

  A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH

  摘要：

  p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.031
• 作为产物：
  描述：

  在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 1-(2-mercaptoethyl)-3-phenylthiourea
  参考文献：
  名称：

  Reactions of Mercaptoamines. I. With Isocyanates and Isothiocyanates¹

  摘要：

  DOI：

  10.1021/jo01046a048

文献信息

• N-Heterocyclic Phosphines
  申请人：The Board of Regents of the Nevada System of Higher Education on Behalf of the Unive. of Nevada

  公开号：US20180118770A1

  公开（公告）日：2018-05-03

  Provided herein are N-heterocyclic phosphines (NHPs) useful in metal-free phosphorus-carbon bond forming reactions. Methods for preparing vinylphosphonates using NHPs also are provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了一种在无金属条件下进行磷-碳键形成反应中有用的N-杂环膦（NHPs）。还提供了使用NHPs制备乙烯磷酸酯的方法。本摘要旨在作为在特定领域搜索的扫描工具，不限制本发明。
• N-heterocyclic phosphines
  申请人：The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas

  公开号：US10633403B2

  公开（公告）日：2020-04-28

  Provided herein are N-heterocyclic phosphines (NHPs) useful in metal-free phosphorus-carbon bond forming reactions. Methods for preparing vinylphosphonates using NHPs also are provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了可用于无金属磷-碳键形成反应的 N-杂环膦（NHPs）。还提供了使用 NHPs 制备乙烯基膦酸盐的方法。本摘要旨在作为一种扫描工具，用于特定技术领域的搜索，而非对本发明的限制。
• A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH
  作者：Uwe Heinelt、Daniela Schultheis、Siegfried Jäger、Marion Lindenmaier、Annett Pollex、Henning S.g. Beckmann

  DOI：10.1016/j.tet.2004.08.031

  日期：2004.10

  p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. (C) 2004 Elsevier Ltd. All rights reserved.
• Reactions of Mercaptoamines. I. With Isocyanates and Isothiocyanates¹
  作者：Arthur F. Ferris、Beverly A. Schutz

  DOI：10.1021/jo01046a048

  日期：1963.11