2-amino-3-(pyrazin-2-yl)propanoic acid | 6705-28-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-3-(pyrazin-2-yl)propanoic acid
• 英文别名: 3-Pyrazinyl-(2)-DL-α-alanin；2-amino-3-pyrazin-2-yl-propionic acid；2-amino-3-pyrazin-2-ylpropanoic acid
• CAS: 6705-28-8
• 化学式: C₇H₉N₃O₂
• 分子量: 167.167
• InChiKey: JNNCNURVELPUNP-UHFFFAOYSA-N

物化性质

• 沸点：
  339.9±42.0 °C(Predicted)
• 密度：
  1.349±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] BACKBONE-CYCLIZED PEPTIDOMIMETICS<br/>[FR] PEPTIDOMIMÉTIQUES À SQUELETTE CYCLISÉ
  申请人：POLYPHOR AG

  公开号：WO2016162127A1

  公开（公告）日：2016-10-13

  Novel backbone-cyclized peptidomimetics of the general formula cyclo[-P1-P2-P3-P4-P5-P6-P7-P8-T1-T2-] (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to modulate the GLP-1 receptor. They can be used as medicaments to treat, prevent, or delay the onset of diseases, disorders or conditions in which modulation of the human GLP-1 receptor is beneficial, such as type 2 diabetes. These backbone-cyclized peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  新型的骨架环化肽类似物的一般公式为cyclo[-P1-P2-P3-P4-P5-P6-P7-P8-T1-T2-]（I），其中单个元素T或P是α-氨基酸残基，以任一方向连接，根据它们在链中的位置，在描述和权利要求中定义，以及其盐，具有调节GLP-1受体的特性。它们可用作药物治疗、预防或延缓调节人类GLP-1受体有益的疾病、紊乱或病况，如2型糖尿病。这些骨架环化肽类似物可通过基于混合固相和溶液相合成策略的过程制造。
• [EN] BETA-HAIRPIN PEPTIDOMIMETICS<br/>[FR] PEPTIDOMIMÉTIQUES EN ÉPINGLE À CHEVEUX BÊTA
  申请人：POLYPHOR AG

  公开号：WO2016050361A1

  公开（公告）日：2016-04-07

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6- P7-P8-P9-P10-P11-P12-T1-T2] a nd pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gramnegative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiellapneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  Beta-发夹肽类似物的一般式(I)，环[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2]及其药学上可接受的盐，其中P1至P12，T1和T2是描述和权利要求中定义的元素，具有抗革兰氏阴性微生物活性，例如抑制生长或杀灭肺炎克雷伯菌、包括鲍曼不动杆菌和/或大肠杆菌等微生物。它们可用作药物治疗或预防感染，或用作食品、化妆品、药物或其他含营养物质的材料的消毒剂。这些肽类似物可以通过基于混合固相和溶液相合成策略的过程制造。
• [EN] NOVEL NON-CODING HETEROCYCLIC AMINO ACIDS (NCHAA) AND THEIR USE AS HERBICIDES<br/>[FR] NOUVEAUX ACIDES AMINÉS HÉTÉROCYCLIQUES NON CODANTS (NCHAA) ET LEUR UTILISATION EN TANT QU'HERBICIDES
  申请人：FORTEPHEST LTD

  公开号：WO2020250223A1

  公开（公告）日：2020-12-17

  The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents such as pesticides or plant growth regulators.

  该发明涉及一种新型的替代氨基酸，包括该新型替代氨基酸的农业组合物，以及它们用于单独或与农作物保护剂（如杀虫剂或植物生长调节剂）结合控制不受欢迎的植物生长的用途。
• BETA-HAIRPIN PEPTIDOMIMETICS
  申请人：POLYPHOR AG

  公开号：US20160052971A1

  公开（公告）日：2016-02-25

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P 1 -p 2 -p 3 -p 4 -p 5 -p 6 -p 7 -p 8 p 9 -p 10 -p 11 -p 12 -T 1 -T 2 ], and pharmaceutically acceptable salts thereof, with P 1 to P 12 , T 1 and T 2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli . They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  一般式（I）的β-发夹肽类似物，其化学式为cyclo[P1-p2-p3-p4-p5-p6-p7-p8p9-p10-p11-p12-T1-T2]及其药用盐，其中P1至P12、T1和T2为描述和索赔中定义的元素，具有抗革兰氏阴性菌活性，例如抑制生长或杀灭肺炎克雷伯氏菌、鲍曼不动杆菌和/或大肠杆菌等微生物。它们可用作药物治疗或预防感染，或用作食品、化妆品、药物或其他营养物质的消毒剂。这些肽类似物可以通过基于混合固相和溶液相合成策略的工艺制造。
• Monomethylvaline Compounds Having Phenylalanine Side-Chain Replacements at the C-Terminus
  申请人：Doronina Svetlana O.

  公开号：US20090018086A1

  公开（公告）日：2009-01-15

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其中包括C-末端苯丙氨酸残基侧链替换或修饰，这些类似物可以单独提供或通过各种连接剂连接到配体上。相关的结合物可以针对特定细胞类型，提供治疗效果。