9-Octadecen-17-ynoic acid | 166664-87-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-Octadecen-17-ynoic acid
• 英文别名: octadec-9-en-17-ynoic acid
• CAS: 166664-87-5
• 化学式: C₁₈H₃₀O₂
• 分子量: 278.4
• InChiKey: GUWNXWGQBCLLBN-UHFFFAOYSA-N

物化性质

• 沸点：
  387.7±25.0 °C(Predicted)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Lipid probes and uses thereof
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10168342B2

  公开（公告）日：2019-01-01

  Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.

  披露了用于识别脂质结合蛋白作为药物结合靶点的方法、组合物、探针、检测和试剂盒。此外，还披露了用于绘制脂质结合蛋白上的配体结合位点、识别脂质结合蛋白、生成药物-脂质结合蛋白轮廓、高通量药物筛选以及识别作为潜在脂质结合蛋白配体的药物的方法、组合物和探针。
• Bi-directionally crosslinked liposomes and method of making same
  申请人：Verily Life Sciences LLC

  公开号：US10842746B1

  公开（公告）日：2020-11-24

  Disclosed herein are methods for producing bi-directionally crosslinked liposomes. The methods include the steps of: providing a lipid composition comprising a plurality of reactive lipids, wherein each of the reactive lipids comprises a reactive hydrophobic group, a reactive hydrophilic group, or a reactive hydrophilic group and a reactive hydrophobic group; forming an un-crosslinked liposome comprising the reactive lipids; and crosslinking at least a portion of the reactive hydrophobic groups or the reactive hydrophilic groups; thereby producing the bi-directionally crosslinked liposomes. Bi-directionally crosslinked liposomes and methods for delivering therapeutic and/or diagnostic agents to subjects using the liposomes are also described.

  本文公开了生产双向交联脂质体的方法。这些方法包括以下步骤：提供包含多种活性脂质的脂质组合物，其中每种活性脂质包含一个活性疏水基团、一个活性亲水基团或一个活性亲水基团和一个活性疏水基团；形成包含活性脂质的未交联脂质体；交联至少一部分活性疏水基团或活性亲水基团；从而生产双向交联脂质体。此外，还描述了双向交联脂质体和使用该脂质体向受试者递送治疗和/或诊断制剂的方法。
• Engineered liposomes as cancer-targeted therapeutics
  申请人：Children's Medical Center Corporation

  公开号：US11260132B2

  公开（公告）日：2022-03-01

  The disclosure provides liposomes (e.g., cancer-targeting liposomes) with ligands (e.g., EGFR ligands and ICAM-1 ligands) conjugated to liposome surfaces. In some embodiments, the molecular ratio of different ligands complement the relative molecular density (i.e., ratio) of overexpressed protein on the surface of a cell targeted by the liposome (e.g., cancer cell).

  本公开提供了脂质体（如癌症靶向脂质体），脂质体表面共轭有配体（如表皮生长因子受体配体和ICAM-1配体）。在一些实施方案中，不同配体的分子比与脂质体靶向细胞（如癌细胞）表面过表达蛋白的相对分子密度（即比值）互补。
• PLANT FATTY ACID HYDROXYLASE GENES
  申请人：CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE

  公开号：EP1021551A1

  公开（公告）日：2000-07-26
• LIPID PROBES AND USES THEREOF
  申请人：The Scripps Research Institute

  公开号：EP3274712A1

  公开（公告）日：2018-01-31