3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-dione | 1616869-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-dione
• 英文别名: spiro[1-benzofuran-2,3'-2H-isoindole]-1',3-dione
• CAS: 1616869-77-2
• 化学式: C₁₅H₉NO₃
• 分子量: 251.241
• InChiKey: FRPRYQOSOBUTTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 2-溴丙二腈 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-dione
  参考文献：
  名称：

  Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3,3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent

  摘要：

  An efficient methodology for the synthesis of 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.027

文献信息

• Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3,3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent
  作者：Ashis Kundu、Sudipta Pathak、Kamalesh Debnath、Animesh Pramanik

  DOI：10.1016/j.tetlet.2014.04.027

  日期：2014.7

  An efficient methodology for the synthesis of 3H,3'H-spiro[benzofuran-2,1'-isoindole]-3,3'-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.