1,2-Diethyl-cyclopropane-1,2-dicarboxylic acid | 90612-97-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2-Diethyl-cyclopropane-1,2-dicarboxylic acid
• 英文别名: 1,2-Diethylcyclopropane-1,2-dicarboxylic acid
• CAS: 90612-97-8
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: RZZYWODHBSLGOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Retroviral protease inhibitors
  申请人：Mueller A. Richard

  公开号：US20060040974A1

  公开（公告）日：2006-02-23

  HIV protease inhibitors are disclosed which are characterized as having both hydroxyethylamine and N-heterocyclic moieties.

  披露了具有羟乙基胺和N-杂环基团的HIV蛋白酶抑制剂。
• Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0007128A1

  公开（公告）日：1980-01-23

  The novel compound 3-benzyl-3-azabicyclo(3.1.0] hexane may be prepared by selective reduction of the carbonyl groups of 3-benzyl-3- azabicyclo[3.1.0] hexan-2,4-dione, using a complex aluminium hydride reducing agent. It may then be used in the preparation of 2-carboxy-3-azabicyclo [3.1.0]hexane, which has valuable biological properties.

  新型化合物 3-苄基-3-氮杂双环[3.1.0]己烷可通过使用复合氢化铝还原剂选择性还原 3-苄基-3-氮杂双环[3.1.0]己烷-2,4-二酮的羰基来制备，然后可用于制备具有重要生物特性的 2-羧基-3-氮杂双环[3.1.0]己烷。
• Modulation of the P2Y2 receptor pathway
  申请人：P2-Science APS

  公开号：EP2036567A2

  公开（公告）日：2009-03-18

  The present invention relates to the field of regulating the activity of the purinergic receptors for the modulation of the vascular tone, particularly for the purpose of treatment of haemodynamic conditions by overriding of vasoconstriction activity, such as increases in sympathic vasoconstriction. Modulators, such as UTP analogues as described herein are preferably specific for P2Y2. Compounds capable of stimulating the P2Y2 receptor are suitable for the treatment or prevention wherein inhibition of vasoconstriction activity is desirable such as hypertension and hypertension relates disorders or diseases, whereas compound capable of counteracting the activity of the P2Y2 receptor are suitable for the treatment of or prevention wherein inhibition of vasodilatation is desirable.

  本发明涉及调节嘌呤能受体活性以调节血管张力的领域，特别是通过抑制血管收缩活性（如交感血管收缩增加）来治疗血流动力学疾病。调节剂，如本文所述的UTP 类似物，最好对 P2Y2 具有特异性。能够刺激 P2Y2 受体的化合物适用于治疗或预防需要抑制血管收缩活性的疾病，如高血压和高血压相关失调或疾病，而能够抵消 P2Y2 受体活性的化合物适用于治疗或预防需要抑制血管舒张的疾病。
• Compounds that bind P2Y2 or P2Y1 receptors
  申请人：——

  公开号：US20040116339A1

  公开（公告）日：2004-06-17

  The invention provides peptides and compounds that can bind to P2Y 2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.

  本发明提供了能与 P2Y 2 受体，可用于调节粘膜表面的粘液分泌。
• COMPOUNDS THAT BIND P2Y sb 2 /sb OR P2Y sb 1 /sb RECEPTORS
  申请人：KIMBERLY-CLARK WORLDWIDE, INC.

  公开号：EP1592436A2

  公开（公告）日：2005-11-09