[(5S)-1-(methylamino)-1-oxotetradecan-5-yl] acetate | 1384069-27-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [(5S)-1-(methylamino)-1-oxotetradecan-5-yl] acetate
• CAS: 1384069-27-5
• 化学式: C₁₇H₃₃NO₃
• 分子量: 299.454
• InChiKey: MQSQHZXBRUZUCV-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [(5S)-1-(methylamino)-1-oxotetradecan-5-yl] acetate 在 sodium hydroxide 、 硫酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230
• 作为产物：
  描述：

  乙酸乙烯酯 、 5-hydroxy-N-methyltetradecanamide 在 Novozym 435 作用下， 以 乙醚 为溶剂， 反应 60.0h， 以43%的产率得到(R)-5-hydroxy-N-methyltetradecanamide
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230