Dihydro-N-α-lipoyl-DL-methionin | 7798-30-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dihydro-N-α-lipoyl-DL-methionin
• 英文别名: 2-[6,8-Bis(sulfanyl)octanoylamino]-4-methylsulfanylbutanoic acid
• CAS: 7798-30-3
• 化学式: C₁₃H₂₅NO₃S₃
• 分子量: 339.544
• InChiKey: BMIMTUMGCHJVSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  93.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Melanin extinguisher
  申请人：Ogata Kazumi

  公开号：US20060122100A1

  公开（公告）日：2006-06-08

  A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.

  一种黑色素消除剂制剂，包括下列式子（I）所表示的金属螯合化合物，其中M表示金属，R表示羟基、O-低烷基、与N键合的胺、与N键合的氨基酸或与N键合的肽，或其药理学上可接受的盐。
• MELANIN ELIMINATOR PREPARATION
  申请人：OGATA Kazumi

  公开号：US20090093541A1

  公开（公告）日：2009-04-09

  A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.

  一种黑色素消除剂制剂，包括由以下式子（I）所代表的金属螯合化合物，其中M代表金属，R代表羟基，O-低碳基，氨基键合在N上，氨基酸键合在N上或肽键合在N上，或其药理学上可接受的盐。
• MELANIN EXTINGUISHER
  申请人：Oga Research, Incorporated

  公开号：EP1547590A1

  公开（公告）日：2005-06-29

  A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.

  一种黑色素消除剂制剂，包含由下式(I)代表的金属螯合物、 其中 M 表示金属，R 表示羟基、O-低级烷基、键合在 N 上的胺、键合在 N 上的氨基酸或键合在 N 上的肽，或其药理学上可接受的盐。
• Tyrosinase activity inhibitor and external preparation for skin
  申请人：JO Cosmetics Co., Ltd.

  公开号：US10632089B2

  公开（公告）日：2020-04-28

  A tyrosinase activity inhibitor is prepared by combining (A) a metal (zinc, cobalt or iron) chelate compound of α-lipoyl amino acid or its pharmaceutically acceptable salt with (B-1) a human manganese SOD or (B-2) an ascorbic acid compound such as ascorbic acid and ascorbyl glucoside. A ratio (R1) of the (B-1) component content to the (A) component content is preferably 0.001 to 1,500, when R1 is defined as R1=[Unit concentration of (B-1) component (unit/mL)/Concentration of (A) component (μg/mL)], and a ratio (R2) of the (A) component content to the (B-2) component content is preferably 0.0001 to 1,000, when R2 is defined as R2=[Concentration of (A) component (m/mL)/Concentration of (B-1) component (mg/mL)]. An external preparation for skin contains the (A) component and the (B-1) component or the (B-2) component as effective ingredients for inhibiting tyrosinase activity.

  将(A)α-脂酰氨基酸的金属（锌、钴或铁）螯合物或其药学上可接受的盐与(B-1)人锰SOD或(B-2)抗坏血酸化合物如抗坏血酸和抗坏血酸葡萄糖苷结合，制备酪氨酸酶活性抑制剂。(B-1)组分含量与(A)组分含量之比(R1)优选为 0.001 至 1,500，当 R1 定义为 R1=[(B-1)组分的单位浓度（单位/毫升）/(A)组分的浓度（微克/毫升）]，(A)组分含量与(B-2)组分含量之比(R2)优选为 0.0001至1,000，当R2定义为R2=[(A)组分的浓度(m/mL)/(B-1)组分的浓度(mg/mL)]时。一种皮肤外用制剂含有(A)成分和(B-1)成分或(B-2)成分，作为抑制酪氨酸酶活性的有效成分。
• Novel a-lipoic acid derivative and use thereof
  申请人：——

  公开号：US20040092586A1

  公开（公告）日：2004-05-13

  A novel a-lipoic acid derivative represented by the following formula (I). It has tyrosinase inhibitory activity, melanin production inhibitory activity, and elastase inhibitory activity. (I) (In the formula, M represents a metal and A represents an amino acid residue bonded through the nitrogen atom.). 1

  一种由下式（I）代表的新型硫辛酸衍生物。它具有酪氨酸酶抑制活性、黑色素生成抑制活性和弹性蛋白酶抑制活性。(I) （式中，M 代表金属，A 代表通过氮原子键合的氨基酸残基）。 1