3-(8-Fluoro-7-hydroxy-4-methyl-2-oxo-2H-chromen-6-yl)propanoic acid | 502484-04-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(8-Fluoro-7-hydroxy-4-methyl-2-oxo-2H-chromen-6-yl)propanoic acid
• 英文别名: 3-(8-Fluoro-7-hydroxy-4-methyl-2-oxochromen-6-yl)propanoic acid
• CAS: 502484-04-0
• 化学式: C₁₃H₁₁FO₅
• 分子量: 266.226
• InChiKey: YRJIYZFXJIELJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOUNDS AND METHODS FOR FLUORESCENT LABELING
  申请人：Lukhtanov A. Eugeny

  公开号：US20050171340A1

  公开（公告）日：2005-08-04

  Dye reagents useful in labeling biological materials are provided along with methods for their use.

  提供了用于标记生物材料的染料试剂以及其使用方法。
• Compounds and methods for fluorescent labeling
  申请人：Lukhtanov A. Eugeny

  公开号：US20050277144A1

  公开（公告）日：2005-12-15

  Dye reagents useful in labeling biological materials are provided along with methods for their use.

  本发明提供了用于标记生物材料的染料试剂以及其使用方法。
• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：Cheng Jianjun

  公开号：US20120178711A1

  公开（公告）日：2012-07-12

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及含有治疗环糊精的聚合物化合物的新型组合物，其设计为小分子治疗药物的载体，以及其制药组合物。这些含有环糊精的聚合物可以提高药物的稳定性和溶解度，并在体内使用时减少小分子治疗药物的毒性。此外，通过从各种连接基团和靶向配体中进行选择，这些聚合物还提供了治疗剂的受控释放方法。本发明还涉及使用上述治疗组合物治疗受试者的方法。本发明还涉及进行制药业务的方法，包括制造、许可或分发包含或涉及上述聚合物化合物的试剂盒。
• EP1466176A4
  申请人：——

  公开号：EP1466176A4

  公开（公告）日：2008-10-01
• EP1991705A2
  申请人：——

  公开号：EP1991705A2

  公开（公告）日：2008-11-19