lead maleate | 90268-66-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lead maleate
• 英文别名: [Pb(μ7-maleate)]n；maleic acid ; lead salt；Maleinsaeure; Bleisalz；Lead(II) maleate；(Z)-but-2-enedioate;lead(2+)
• CAS: 90268-66-9
• 化学式: C₄H₂O₄*Pb
• 分子量: 321.257
• InChiKey: JJWLMSCSLRJSAN-ODZAUARKSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.34
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 副作用

神经毒素 - 主要影响运动功能 职业性肝毒素 - 次级肝毒素：职业环境中潜在的有毒效应基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学物质在职业环境中可能对肾脏有毒。 溶血性贫血 - 降低血红蛋白或红细胞数量。 生殖毒素 - 对生殖系统有毒的化学物质，包括对后代缺陷以及损害男性或女性生殖功能的损伤。生殖毒性包括发育效应。参见生殖毒性风险评估指南。 国际癌症研究机构(IARC)致癌物 - 2类：国际癌症研究机构将化学物质分类为很可能（2a）或可能（2b）的人类致癌物。 美国国家毒理学项目(NTP)致癌物 - 有理由预期为人类致癌物。 美国工业卫生学会(ACGIH)致癌物 - 动物实验确认。

Neurotoxin - Predominantly motor Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Hemolytic anemia - Decreased hemoglobin or number of red blood cells. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment. IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens. NTP Carcinogen - Reasonably anticipated to be a human carcinogen. ACGIH Carcinogen - Confirmed Animal.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

反应信息

• 作为反应物：
  描述：

  lead maleate 以 neat (no solvent, solid phase) 为溶剂， 生成 lead(II) oxide
  参考文献：
  名称：

  Sonochemical synthesis of a new nano-plate lead(II) coordination polymer constructed of maleic acid

  摘要：

  A new nano-sized lead(II) coordination polymer of maleic acid (H(2)Mal), [Pb(mu(7)-Mal)](n) (1), has been synthesized by sonochemical method and characterized by scanning electron microscopy, X-ray powder diffraction, elemental analyses and IR spectroscopy. The compound 1 was structurally characterized by single-crystal X-ray diffraction. Thermal stability of nano and bulk samples of compound 1 were studied and compared with each other. After calcination of nano-sized compound 1 at 600 degrees C, pure phase microsized lead(II) oxide has been produced. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.04.024
• 作为产物：
  描述：

  lead(II) nitrate 、 顺丁烯二酸 以 水 为溶剂， 以51%的产率得到lead maleate
  参考文献：
  名称：

  Sonochemical synthesis of a new nano-plate lead(II) coordination polymer constructed of maleic acid

  摘要：

  A new nano-sized lead(II) coordination polymer of maleic acid (H(2)Mal), [Pb(mu(7)-Mal)](n) (1), has been synthesized by sonochemical method and characterized by scanning electron microscopy, X-ray powder diffraction, elemental analyses and IR spectroscopy. The compound 1 was structurally characterized by single-crystal X-ray diffraction. Thermal stability of nano and bulk samples of compound 1 were studied and compared with each other. After calcination of nano-sized compound 1 at 600 degrees C, pure phase microsized lead(II) oxide has been produced. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.04.024

文献信息

• Tribasic Lead Maleate and Lead Maleate:  Synthesis and Structural and Spectroscopic Characterizations
  作者：François Bonhomme、Todd M. Alam、Aaron J. Celestian、David R. Tallant、Timothy J. Boyle、Brian R. Cherry、Ralph G. Tissot、Mark A. Rodriguez、John B. Parise、May Nyman

  DOI：10.1021/ic050611y

  日期：2005.10.1

  We report on the synthesis and structure of tribasic lead maleate hemihydrate ([Pb4O3]C2H2(CO2)2.(1/2)H2O, TRIMAL) and lead maleate (PbC2H2(CO2)2, PBMAL). The structure of [Pb4O3]C2H2(CO2)2.(1/2)H2O, solved ab initio from X-ray powder diffraction data, consists of infinite slabs of edge-sharing OPb4 tetrahedra, of composition [Pb4O3], running along the c axis and linked together into a three-dimensional

  我们报告了三碱马来酸铅半水合物（[Pb4O3] C2H2（CO2）2.（1/2）H2O，TRIMAL）和马来酸铅（PbC2H2（CO2）2，PBMAL）的合成和结构。从X射线粉末衍射数据从头开始求解的[Pb4O3] C2H2（CO2）2.（1/2）H2O的结构由边沿互为边界的OPb4四面体，组成为[Pb4O3]的无限平板组成。 c轴并通过马来酸四齿阴离子配体连接在一起形成三维网络。由单晶衍射数据解析得到的PbC2H2（CO2）2的结构为层状，包含双层七配位的铅原子，仅与马来酸酯配体的氧原子键合。在这两种化合物中，铅均为2+氧化态，Pb2 +周围的配位多面体呈现半定向几何形状，并且由于孤对电子而严重扭曲。通过拉曼光谱以及通过1H MAS和1H-13C CP MAS NMR实验证实了在马来酸酯部分的酸性部分上不存在质子。使用化学和热重分析进一步表征了这两种化合物。
• KIZLINK J.; RATTAY V.; JAKUBCEK E., ROPA A UHLIE, 29,(1987) N 4, 199-201
  作者：KIZLINK J.、 RATTAY V.、 JAKUBCEK E.

  DOI：——

  日期：——
• Sonochemical synthesis of a new nano-plate lead(II) coordination polymer constructed of maleic acid
  作者：Leila Aboutorabi、Ali Morsali

  DOI：10.1016/j.ica.2010.04.024

  日期：2010.8

  A new nano-sized lead(II) coordination polymer of maleic acid (H(2)Mal), [Pb(mu(7)-Mal)](n) (1), has been synthesized by sonochemical method and characterized by scanning electron microscopy, X-ray powder diffraction, elemental analyses and IR spectroscopy. The compound 1 was structurally characterized by single-crystal X-ray diffraction. Thermal stability of nano and bulk samples of compound 1 were studied and compared with each other. After calcination of nano-sized compound 1 at 600 degrees C, pure phase microsized lead(II) oxide has been produced. (C) 2010 Elsevier B.V. All rights reserved.