4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-5-(2-trihydroxydiphosphoryloxy-ethyl)-thiazolium; chloride | 60721-90-6

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-5-(2-trihydroxydiphosphoryloxy-ethyl)-thiazolium; chloride
• 英文别名: 4-Methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-5-(2-trihydroxydiphosphoryloxy-aethyl)-thiazolium; Chlorid；2-[4-methyl-3-[(2-methyl-6-oxo-1H-pyrimidin-5-yl)methyl]-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate;chloride
• CAS: 60721-90-6
• 化学式: C₁₂H₁₈N₃O₈P₂S*Cl
• 分子量: 461.757
• InChiKey: PPRBRQNNPHLUIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.44
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  187
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 PPA 作用下， 生成 4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-5-(2-trihydroxydiphosphoryloxy-ethyl)-thiazolium; chloride
  参考文献：
  名称：

  Velluz et al., Bulletin de la Societe Chimique de France, 1950, p. 297,300

  摘要：

  DOI：

文献信息

• Synthesis and characterization of catalytically active thiazolium gold(<scp>i</scp>)-carbenes
  作者：Clément C. Dince、Roy A. Meoded、Donald Hilvert

  DOI：10.1039/c7cc03791k

  日期：——

  Thiamin analogs were used to synthesize mono gold(I)-carbene derivatives in a single step under aqueous conditions. The resulting thiazolium gold(I)-carbenes catalyze 5-endo-dig carbocyclization of an acetylenic dicarbonyl compound in organic solvents and hydroalkoxylation of an allene in aqueous buffer.

  硫胺类似物用于在水性条件下一步合成单金（I）-卡宾衍生物。所得的噻唑鎓金（I）-卡宾在有机溶剂中催化炔属二羰基化合物的5-内挖式碳环化，以及在水性缓冲液中丙二烯的加氢烷氧基化。
• Methods for the positive selection of ethanol overproducing mutants from Saccharomyces cerevisiae
  申请人：Archer Daniels Midland Company

  公开号：US10577580B2

  公开（公告）日：2020-03-03

  Described herein are new approaches for the selection of S. cerevisiae strains with increased ethanol production from hydrolyzed starch derived sugars. An industrial production strain of Saccharomyces cerevisiae AS400 was subjected to positive selection of mutants resistant to toxic concentrations of oxythiamine, trehalose, 3-bromopyruvate, glyoxylic acid, and glucosamine. The selected mutants are characterized by 5-8% increase in ethanol yield (g g−1 of consumed glucose) as compared to the parental industrial ethanol-producing strain. A multiple-step selection approach that consisted of the sequential selection using glyoxylic acid, glucosamine and bromopyruvate as selective agents resulted in a 12% increase in ethanol yield during fermentation on industrial media. These results indicate that the selection methods provided herein are useful for producing a variety of strains that are promising candidates for industrial ethanol production.

  本文介绍了从水解淀粉衍生的糖中选择乙醇产量更高的酿酒酵母菌株的新方法。对一株工业化生产的酿酒酵母（Saccharomyces cerevisiae）AS400 进行了正向选择，选出了对有毒浓度的氧硫胺、曲哈糖、3-溴丙酮酸、乙醛酸和氨基葡萄糖具有抗性的突变体。与亲本工业乙醇生产菌株相比，所选突变体的乙醇产量（消耗的葡萄糖克重）提高了 5-8%。通过使用乙醛酸、氨基葡萄糖和溴丙酮酸作为选择剂进行多步选择，工业培养基发酵过程中的乙醇产量提高了 12%。这些结果表明，本文提供的选择方法可用于生产各种菌株，这些菌株有望用于工业乙醇生产。
• Pure crystalline oxythiamine phosphoric esters preparation and some chemical and biological properties
  作者：F. Navazio、N. Siliprandi、A. Rossi-Fanelli

  DOI：10.1016/0006-3002(56)90428-0

  日期：1956.1
• Koike, 1955, vol. 8, p. 366,367
  作者：Koike

  DOI：——

  日期：——
• Onrust et al., Enzymology, <hi>1953</hi>, vol. 15, p. 351,352
  作者：Onrust et al.

  DOI：——

  日期：——