N-[[3-(formamidomethyl)cyclohexyl]methyl]formamide | 136869-17-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[[3-(formamidomethyl)cyclohexyl]methyl]formamide
• CAS: 136869-17-5
• 化学式: C₁₀H₁₈N₂O₂
• 分子量: 198.265
• InChiKey: YHQPYYJUZPIVDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[[3-(formamidomethyl)cyclohexyl]methyl]formamide 在 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 1,3-bis(isocyanomethyl)cyclohexane
  参考文献：
  名称：

  Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids

  摘要：

  A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.071
• 作为产物：
  描述：

  甲酸 、 1,3-环己二甲胺 以 甲苯 为溶剂， 反应 8.0h， 生成 N-[[3-(formamidomethyl)cyclohexyl]methyl]formamide
  参考文献：
  名称：

  Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids

  摘要：

  A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.071

文献信息

• A back sheet for photovoltaic modules
  申请人：AGFA-GEVAERT

  公开号：EP2746322B1

  公开（公告）日：2018-03-07
• METHOD FOR LAMINATION OF DECORATIVE METAL FILM ON RESIN BASE MATERIAL, AND RESIN BASE MATERIAL HAVING DECORATIVE METAL FILM THEREON
  申请人：Irikura Hagane

  公开号：US20100209721A1

  公开（公告）日：2010-08-19

  The present invention provides a method for laminating a decorative metal film on a resin base material with excellent adhesion to the resin base material and with a sufficient gloss imparted to the decorative metal film, and a resin base material having a decorative metal film. The method laminates a polymeric planarizing film on the resin base material using a vapor deposition polymerization method, and then laminates the decorative metal film on the planarizing film.
• Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids
  作者：Waldemar Goldeman、Anna Nasulewicz-Goldeman

  DOI：10.1016/j.bmcl.2014.05.071

  日期：2014.8

  A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid. (C) 2014 Elsevier Ltd. All rights reserved.