N,N,N',N'-tetraethyl methylsuccindiamide | 100528-17-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N,N',N'-tetraethyl methylsuccindiamide
• 英文别名: methyl-succinic acid bis-diethylamide；N,N,N',N'-Tetraaethyl-2-methyl-succinamid；Methyl-bernsteinsaeure-bis-diaethylamid；N,N,N',N'-tetraethyl-2-methylbutanediamide
• CAS: 100528-17-4
• 化学式: C₁₃H₂₆N₂O₂
• 分子量: 242.362
• InChiKey: UPKMGHCJGAZVFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  17.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  40.62
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  N,N,N',N'-tetraethyl-2-methylidenepropanediamide 以83%的产率得到
  参考文献：
  名称：

  KOLLAR, LASZLO;CONSIGLIO, GIAMBATTISTA;PINO, PIERO, J. ORGANOMET. CHEM., 386,(1990) N, C. 389-394

  摘要：

  DOI：

文献信息

• Reactions of unsaturated amides under hydroformylation conditions
  作者：László Kollár、Giambattista Consiglio、Piero Pino

  DOI：10.1016/0022-328x(90)80010-w

  日期：1990.4

  undergoes hydroformylation, followed by subsequent reactions, under “oxo” conditions involving use of Rh4(CO)12 or Rh4(CO)12 in the presence of (R,R)-Diop (Diop = 2,2-dimethyl-1,3-dioxolane-4,5-diylbis (methylene)bis(diphenylphosphine)) as the catalyst precursor. The product first formed arises from formylation at the unsubstituted unsaturated carbon atom, and subsequently gives α-methyl-γ-butyrolactone

  Ñ，Ñ二乙基甲基丙烯酰胺（1）加氢甲酰化经历，然后随后的反应，包括使用的Rh的“氧代”的条件下4（CO）12或Rh 4（CO）12中的存在（- [R ，- [R）-Diop（ Diop ＝ 2，2-二甲基-1，3-二氧戊环-4，5-二基双（亚甲基）双（二苯基膦））作为催化剂前体。最初形成的产物是由未取代的不饱和碳原子上的甲酰化产生的，然后生成α-甲基-γ-丁内酯（1b），N，N - N-二乙基2-甲基-4-羟基丁酰胺（1e）和N，N-二乙基1-甲基-3-（二乙基氨基）丁酰胺（1f）。底物的氢化也发生。反应条件会严重影响产物的分布。对于Ñ，Ñ，Ñ '，Ñ 'N'-四itacon二酰胺（2）类似的反应条件下仅氢化和异构化产物而形成。
• Prevalence and etiology of vertigo in adult rural population
  作者：Raman Abrol、Vikas I. Nehru、Y. Venkatramana

  DOI：10.1007/bf02910976

  日期：2001.1

  A survey on 10.000 adults between the age of 20 and 79 years out of a total population of 66.186 persons in rural settlements under the inrisduction of Union Territory of Chandigarh between June 1993 to June 1995 was conducted to find out the prevalence and various causes of vertigo. In general community, in rural population, we found that more people suffer from non-otologic vertigo rather than otologic vertigo. We found overall prevalence of vertigo in rural adult community to be 0.71%. Vertigo secondary to cardiovascular disease was most common and prevalent in 0.32% of population. Neurologic disease accounted for vertigo in 0.14%, metabolic disease in 0.09% and otologic disease 0.08%. Miscellaneous disorders were present in remaining 0.08% of population studied. To the best of our knowledge this study represents the first population based survey of prevalence of various causes of vertigo in general community in adult rural population.
• Aminodihydrofuramides from 3-Amino-1-propynes and Carbon Monoxide
  作者：J. C. Sauer、B. W. Howk、R. T. Stiehl

  DOI：10.1021/ja01512a047

  日期：1959.2