(E)-N-(4-fluorobenzyl)-N'-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide | 1421692-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-(4-fluorobenzyl)-N'-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide
• 英文别名: N-[(4-fluorophenyl)methyl]-N-[(E)-(4-fluorophenyl)methylideneamino]-4-methylbenzenesulfonamide
• CAS: 1421692-88-7
• 化学式: C₂₁H₁₈F₂N₂O₂S
• 分子量: 400.449
• InChiKey: WTTRYEMQZZJWJR-ZVHZXABRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  p-fluorobenzaldehyde tosylhydrazone 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以85%的产率得到(E)-N-(4-fluorobenzyl)-N'-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide
  参考文献：
  名称：

  N-Alkylation of tosylhydrazones via a metal-free reductive coupling procedure

  摘要：

  A simple metal-free route for the N-alkylation of tosylhydrazones is described via the NaOMe-promoted reductive coupling of tosylhydrazones under mild conditions. A wide variety of N-alkylated tosylhydrazones were obtained in moderate to good yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.124

文献信息

• N-Alkylation of tosylhydrazones via a metal-free reductive coupling procedure
  作者：Jin-Biao Liu、Hui Yan、Gui Lu

  DOI：10.1016/j.tetlet.2012.11.124

  日期：2013.2

  A simple metal-free route for the N-alkylation of tosylhydrazones is described via the NaOMe-promoted reductive coupling of tosylhydrazones under mild conditions. A wide variety of N-alkylated tosylhydrazones were obtained in moderate to good yields. (C) 2012 Elsevier Ltd. All rights reserved.