2-Amino-8-hydroxyoctanoic acid | 83972-20-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-8-hydroxyoctanoic acid
• CAS: 83972-20-7
• 化学式: C₈H₁₇NO₃
• 分子量: 175.228
• InChiKey: BXWIRZWJUWLKSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Amino-8-hydroxyoctanoic acid 生成 methyl (2S)-2-benzyloxycarbonylamino-8-oxooctanoate
  参考文献：
  名称：

  Asymmetric synthesis of α-amino acids by alkylation of a glycine amide derivative bearing chiral 2,5-disubstituted pyrrolidine as an amine component

  摘要：

  DOI：

  10.1016/s0040-4039(00)84807-8
• 作为产物：
  描述：

  在 盐酸 作用下， 以91.2%的产率得到2-Amino-8-hydroxyoctanoic acid
  参考文献：
  名称：

  Asymmetric synthesis of α-amino acids by alkylation of a glycine amide derivative bearing chiral 2,5-disubstituted pyrrolidine as an amine component

  摘要：

  DOI：

  10.1016/s0040-4039(00)84807-8

文献信息

• TUMOR TARGETING AGENTS AND USES THEREOF
  申请人：Karyon OY

  公开号：EP1549667A1

  公开（公告）日：2005-07-06
• Tumor targeting agents and uses thereof
  申请人：Bergman Mathias

  公开号：US20060263294A1

  公开（公告）日：2006-11-23

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• [EN] TUMOR TARGETING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE CIBLAGE TUMORAL ET LEURS UTILISATIONS
  申请人：KARYON OY

  公开号：WO2004031219A1

  公开（公告）日：2004-04-15

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• [EN] TUMOR TARGETING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE CIBLAGE TUMORAL ET UTILISATIONS DE CEUX-CI
  申请人：KARYON OY

  公开号：WO2004031220A1

  公开（公告）日：2004-04-15

  This invention relates to novel tumor targeting motifs, units and agents, as well as tumor targeting peptides and ana-logues thereof. The targeting agents typically comprise at least one targeting motif, Aa-Bb-Cc, and at least one ef-fector unic. The invention further relates to specific tumor targeting peptides, pharmaceutical and diagnostic com-posisitons comprising such peptides. Disclosed are also methods for diagnosing or treating cancer.
• Asymmetric synthesis of α-amino acids by alkylation of a glycine amide derivative bearing chiral 2,5-disubstituted pyrrolidine as an amine component
  作者：Satoru Ikegami、Takashi Hayama、Tsutomu Katsuki、Masar-u Yamaguchi

  DOI：10.1016/s0040-4039(00)84807-8

  日期：1986.1