(E,E)-N-Benzyl-N-methyl-nonadienylamin | 73350-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E,E)-N-Benzyl-N-methyl-nonadienylamin
• 英文别名: (2E,4E)-N-benzyl-N-methylnona-2,4-dien-1-amine
• CAS: 73350-35-3
• 化学式: C₁₇H₂₅N
• 分子量: 243.392
• InChiKey: UFEKVAIZWWSRSZ-ZYUHXDNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基苄胺 在 氢氧化钾 、 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 (E,E)-N-Benzyl-N-methyl-nonadienylamin
  参考文献：
  名称：

  Synthesis of Stereodefined Polysubstituted Olefins. 1. Sequential Intermolecular Reactions Involving Selective, Stepwise Insertion of Pd(0) into Allylic and Vinylic Halide Bonds. The Stereoselective Synthesis of Disubstituted Olefins¹

  摘要：

  Palladium-catalyzed allylic substitution and cross-coupling reactions have been combined into a sequential procedure to provide a range of disubstituted olefin products starting from two-, three-, and four-carbon common olefin templates. Diverse application of this template strategy is demonstrated in a variety of model studies and in a parallel synthesis (combinatorial) approach to prepare an allylic amine molecular library. An approach toward the preparation of astaxanthin beta -D-diglucoside, an interesting antioxidant whose total synthesis has yet to be reported, using the olefin-template approach is also discussed.

  DOI：

  10.1021/jo001045l

文献信息

• Synthesis of Stereodefined Polysubstituted Olefins. 1. Sequential Intermolecular Reactions Involving Selective, Stepwise Insertion of Pd(0) into Allylic and Vinylic Halide Bonds. The Stereoselective Synthesis of Disubstituted Olefins¹
  作者：Michael G. Organ、Jeremy T. Cooper、Lawrence R. Rogers、Fariba Soleymanzadeh、Timothy Paul

  DOI：10.1021/jo001045l

  日期：2000.11.1

  Palladium-catalyzed allylic substitution and cross-coupling reactions have been combined into a sequential procedure to provide a range of disubstituted olefin products starting from two-, three-, and four-carbon common olefin templates. Diverse application of this template strategy is demonstrated in a variety of model studies and in a parallel synthesis (combinatorial) approach to prepare an allylic amine molecular library. An approach toward the preparation of astaxanthin beta -D-diglucoside, an interesting antioxidant whose total synthesis has yet to be reported, using the olefin-template approach is also discussed.