(2S)-5-(二氨基亚甲基氨基)-2-[(4-甲基苯基)磺酰基氨基]-N-(4-硝基苯基)戊酰胺 | 36186-55-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S)-5-(二氨基亚甲基氨基)-2-[(4-甲基苯基)磺酰基氨基]-N-(4-硝基苯基)戊酰胺
• 英文名称: N(alpha)-Tosylarginine-4-nitroanilide
• 英文别名: (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]-N-(4-nitrophenyl)pentanamide
• CAS: 36186-55-7
• 化学式: C19H24N6O5S
• 分子量: 448.5
• InChiKey: PSEZMMMPQYFCHI-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  194
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Process for producing arginyl-p-nitroanilide
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0137742A1

  公开（公告）日：1985-04-17

  An Nα-protected-NG-protected-arginyl-p-nitroanilide with high purity can be produced in high yield by reacting an Nα-protected-NG-protected-arginine with p-nitroaniline in pyridine in the presence of a condensing agent.

  在有缩合剂存在的情况下，将 Nα-保护-NG-保护-精氨酸与对硝基苯胺在吡啶中进行反应，可以高产率地生产出高纯度的 Nα-保护-NG-保护-精氨酰-对硝基苯胺。
• Substrates for determination of enzyme activity
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0350915A2

  公开（公告）日：1990-01-17

  Compounds represented by the following formula: wherein A1 and A2 each represents a specific amino acid residue, are excellent as substrates for determination of enzyme activity such as trypsin, etc.

  下式所代表的化合物 其中 A1 和 A2 各代表一个特定的氨基酸残基，是测定胰蛋白酶等酶活性的极佳底物。
• Assay, employing analog to digital signaling, for the presence of an analyte in a sample in conjunction with a binding component, apparatus for performing said process, and a method of performing said assay
  申请人：ENZYMATICS, INC.

  公开号：EP0494509A1

  公开（公告）日：1992-07-15

  An assay, method of performing said assay, and apparatus, capable of generating an "on"/"off" response from a changing concentration of sample analyte, are described. The assay system comprises a high affinity binding component for a sample analyte and has an analyte dissociation constant substantially less than the concentration of analyte to be measured. Under initial conditions, wherein there is an absence of added analyte, a substantial number of binding sites must be empty. The concentration of empty binding sites determines the threshold analyte concentration, or "trigger point," for the "on"/"off" switch. Also required are a means for determining when excess analyte is present after the binding sites are substantially completely filled, wherein said means has an affinity for analyte which is substantially less than the binding component affinity for analyte. Also described is a diagnostic apparatus, comprising a set of compartments, each with a different threshold analyte concentration. A signal is generated in each compartment only when the analyte concentration is greater than the preset threshold, allowing instrument-independent, accurate measurement of analyte concentration.

  本文描述了一种能够根据样品分析物浓度的变化产生 "开"/"关 "响应的检测方法、执行所述检测的方法和仪器。该检测系统包括一个与样品分析物高亲和力结合的组件，其分析物解离常数大大小于待测分析物的浓度。在没有添加分析物的初始条件下，大量的结合位点必须是空的。空结合位点的浓度决定了 "开"/"关 "开关的阈值分析物浓度或 "触发点"。还需要一种方法，用于在结合位点基本完全填满后确定何时存在过量的分析物，其中所述方法对分析物的亲和力大大低于结合元件对分析物的亲和力。 还描述了一种诊断设备，包括一组隔室，每个隔室都有不同的分析物阈值浓度。只有当被分析物浓度大于预设阈值时，才会在每个隔室中产生信号，从而实现与仪器无关的、精确的被分析物浓度测量。
• Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0513863A1

  公开（公告）日：1992-11-19

  Novel compounds represented by the following formula: wherein A and B each represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides.

  下式所代表的新型化合物： 其中 A 和 B 各代表一个特定的氨基酸残基，是测定胰蛋白酶等酶活性的极佳底物。这些化合物可由新型精氨酰-3-叔烷氧基羰基-4-硝基苯胺合成。
• US4564695A
  申请人：——

  公开号：US4564695A

  公开（公告）日：1986-01-14