2,3-dibromo-5-phenylpentanoic acid | 138034-97-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-dibromo-5-phenylpentanoic acid
• 英文别名: 2,3-dibromo-5-phenyl-valeric acid；α.β-Dibrom-δ-phenyl-n-valeriansaeure；2,3-Dibrom-5-phenyl-valeriansaeure
• CAS: 138034-97-6
• 化学式: C₁₁H₁₂Br₂O₂
• 分子量: 336.023
• InChiKey: ZMYKEUXKORKCDP-UHFFFAOYSA-N

物化性质

• 沸点：
  395.3±42.0 °C(Predicted)
• 密度：
  1.736±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2,3-dibromo-5-phenylpentanoic acid 在 potassium carbonate 作用下， 生成 (2E,4E)-5-苯基-2,4-戊二烯酸
  参考文献：
  名称：

  Michael; Garner, American Chemical Journal, 1906, vol. 35, p. 265

  摘要：

  DOI：
• 作为产物：
  描述：

  5-phenylpent-2-enoic acid 在 氯仿 、 溴 作用下， 生成 2,3-dibromo-5-phenylpentanoic acid
  参考文献：
  名称：

  Michael; Garner, American Chemical Journal, 1906, vol. 35, p. 265

  摘要：

  DOI：

文献信息

• Preparation of Vinyl Arenes by Nickel-Catalyzed Reductive Coupling of Aryl Halides with Vinyl Bromides
  作者：Jiandong Liu、Qinghua Ren、Xinghua Zhang、Hegui Gong

  DOI：10.1002/anie.201607959

  日期：2016.12.12

  This work emphasizes the synthesis of substituted vinyl arenes by reductive coupling of aryl halides with vinyl bromides under mild and easy‐to‐operate nickel‐catalyzed reaction conditions. A broad range of aryl halides, including heteroaromatics, and vinyl bromides were employed to yielding products in moderate to excellent yields with high functional‐group tolerance. The nickel‐catalytic system displays

  这项工作强调了在温和且易于操作的镍催化反应条件下，通过芳基卤化物与乙烯基溴的还原偶联来合成取代的乙烯基芳烃。广泛使用的芳基卤化物，包括杂芳族化合物和乙烯基溴化物，以中等至优异的收率生产了具有高官能团耐受性的产品。镍催化系统在两个C（sp 2）-卤化物偶合体之间显示出良好的化学选择性，从而证明了不同于其他逐步方案的机理途径。
• Pinhey, John T.; Stoermer, Martin J., Journal of the Chemical Society. Perkin transactions I, 1991, # 10, p. 2455 - 2460
  作者：Pinhey, John T.、Stoermer, Martin J.

  DOI：——

  日期：——
• Why do Patients with Rheumatoid Arthritis use Alternative Treatments?
  作者：J. W. G. Jacobs、F. W. Kraaimaat、J. W. J. Bijlsma

  DOI：10.1007/pl00011199

  日期：2001.5

  The aim of this study was to analyse the characteristics of patients with rheumatoid arthritis (RA) who make use of alternative or complementary medicine (CM). Two hundred and sixty-two randomly chosen patients with RA filled out self-assessment health status and pain questionnaires. Differences between the group of patients making use of both CM and conventional treatment (n = 52) and the group of patients who relied only on conventional treatment prescribed by their rheumatologists (n = 210) were explored with respect to demographic characteristics, duration of RA, levels of physical, psychological and social functioning, and pain-coping behaviour. We found that female patients used CM more often than did male patients, and those who used CM were younger than those who did not. There were no differences with respect to duration of RA, physical, psychological or social functioning or pain coping; however, the perceived impact of RA on several domains of life was higher in patients who used CM than in those who did not. Nevertheless, the patient groups did not differ in terms of medical consumption, except that those who used CM visited medical specialists for RA-related complaints less than those who relied only on conventional treatments. We concluded that the higher impact of RA, in the absence of worse disease, perceived by users of CM in several domains of life, especially psychosocial functioning, could be the reason they use CM. This suggests that CM cannot be substituted by additional conventional treatment prescribed by the rheumatologist, but rather by psychosocial intervention.
• Fittig; Perrin, Justus Liebigs Annalen der Chemie, 1894, vol. 283, p. 326
  作者：Fittig、Perrin

  DOI：——

  日期：——