α-Pyrone-3-carboxamide | 18398-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: α-Pyrone-3-carboxamide
• 英文别名: 2-oxo-2H-pyran-3-carboxylic acid amide；2-Oxopyran-3-carboxamide
• CAS: 18398-82-8
• 化学式: C₆H₅NO₃
• mdl: MFCD19208689
• 分子量: 139.111
• InChiKey: IGMWATZLERLIIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyridone derivatives as NK3 antagonists
  申请人：Khanzhin Nikolay

  公开号：US20110144164A1

  公开（公告）日：2011-06-16

  The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

  本发明涉及在治疗中有用的化合物，特别是在治疗精神病方面，涉及包含该化合物的组合物，以及包括给予该化合物的治疗方法。
• [EN] PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS<br/>[FR] DÉRIVÉS DE PYRIDONE ANTAGONISTES DE NK3
  申请人：LUNDBECK & CO AS H

  公开号：WO2011072691A1

  公开（公告）日：2011-06-23

  The present invention relates to compound of formula (I) useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

  本发明涉及一种具有式（I）的化合物，用于治疗，特别是在治疗精神病方面，包括所述化合物的组合物，以及通过给予该化合物来治疗疾病的方法。
• Octahydro-1H-benzo(4,5)furo(3,2-e)isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0009780A2

  公开（公告）日：1980-04-16

  Octahydro-1H-benzo[4,5]furo [3,2-e]isoquinoline compounds and processes for their manufacture are provided. The compounds correspond to the formula These compounds exhibit both analgesic and narcotic antagonistic properties, as well as low abuse liability. Novel intermediate compounds are also provided which have the formula CROSS REFERENCE TO RELA TED APPLlCATIONS This application is a continuation-in-part of copending application Serial No. 948,038, filed October 2, 1978.

  提供了八氢-1H-苯并[4,5]呋喃并[3,2-e]异喹啉化合物及其制造工艺。这些化合物的化学式为 这些化合物具有镇痛和麻醉拮抗特性，滥用可能性低。 本研究还提供了新的中间体化合物，其分子式为 相关参考文献 本申请是 1978 年 10 月 2 日提交的序列号为 948,038 的共同申请的部分延续。
• PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS
  申请人：H. Lundbeck A/S

  公开号：EP2513061A1

  公开（公告）日：2012-10-24
• JPH01272556A
  申请人：——

  公开号：JPH01272556A

  公开（公告）日：1989-10-31