2,4-bismethylthio-butanoic acid | 99115-99-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4-bismethylthio-butanoic acid
• 英文别名: BMBA；2,4-Bis(methylthio)butyric acid；2,4-bis(methylsulfanyl)butanoic acid
• CAS: 99115-99-8
• 化学式: C₆H₁₂O₂S₂
• 分子量: 180.292
• InChiKey: NGYPZWVLQXBEJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium thiomethoxide 、 alkaline earth salt of/the/ methylsulfuric acid 在 甲苯 作用下， 生成 2,4-bismethylthio-butanoic acid
  参考文献：
  名称：

  Synthesis of DL-Dimethyldihydro-α-lipoic Acid

  摘要：

  DOI：

  10.1021/ja01624a056

文献信息

• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• DERIVATIVES OF DIHYDROXYPHENYLALANINE
  申请人：Susilo Gisela

  公开号：US20090285888A1

  公开（公告）日：2009-11-19

  The invention relates to derivatives of dihydroxyphenylalanine, to their synthesis and to pharmaceutical compositions containing said derivatives of dihydroxyphenylalanine. Furthermore, the invention relates to the use of said derivatives of dihydroxyphenylalanine and said pharmaceutical compositions for the treatment and prophylaxis of movement disorders, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, hemiparkinson-hemiatrophy, parkinsonian syndrome, Lewy body disease, frontotemporal dementia, Lytico-Bodig disease (parkinsonism/dementia/amyotrophic lateral sclerosis), striatonigral degeneration, Shy-Drager syndrome, sporadic olivopontocerebellar degeneration, progressive atrophy of the globus pallidus, progressive supranuclear palsy, Hallervorden-Spatz disease, Huntington's disease, X-linked dystonia-parkinsonism (Lubag), mitochondrial cytopathy with striatal necrosis, neuroacanthocytosis, restless legs syndrome, Wilson's disease.

  本发明涉及二羟基苯丙氨酸衍生物、其合成方法以及含有该二羟基苯丙氨酸衍生物的制药组合物。此外，本发明还涉及使用该二羟基苯丙氨酸衍生物和该制药组合物治疗和预防运动障碍、神经退行性疾病、阿尔茨海默病、帕金森病、半侧帕金森萎缩症、帕金森综合症、Lewy小体病、颞叶额叶痴呆、Lytico-Bodig病（帕金森症状/痴呆/肌萎缩性侧索硬化症）、纹状体黑质变性、Shy-Drager综合症、散发性橄榄桥小脑变性、球状体进行性萎缩、进行性核上性麻痹、Hallervorden-Spatz病、亨廷顿病、X连锁性肌张力障碍帕金森症（Lubag）、线粒体细胞病伴有纹状体坏死、神经棘细胞病、不宁腿综合症、威尔逊病的用途。
• DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION
  申请人：Dietz Ulrich

  公开号：US20130090488A1

  公开（公告）日：2013-04-11

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及溶解化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸特别是脂肪酸和含有至少一种氨基甲酰基和/或肼基团的溶解化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。溶解化合物的溶解效果与本发明所述的羧酸分离方法相结合，可用于治疗需要去除脂肪酸或从血液中分析羧酸或处理食品、药品、化学、生物燃料工业或其他工业加工过程中的其他溶液的人员。
• Vorrichtung und Verfahren zur Gewinnung von Glycoglycerolipiden und Glycosphingolipiden aus lipoiden Phasen
  申请人：Nanoscience for life GmbH & Co. KG

  公开号：EP2952565A1

  公开（公告）日：2015-12-09

  Die vorliegende Erfindung betrifft eine Vorrichtung und Verfahren zur schonenden und hydrolysefreien Abtrennen von Glycoglycerolipiden als auch von Glycoglycerolipiden und Glycosphingolipiden aus einer lipoiden Phase, welche Glycoglycerolipide und Acylglyceride oder Glycoglycerolipide und Glycosphingolipide und Acylglyceride enthält unter gleichzeitiger effektiver Abreicherung der lipoiden Phasen von besagten Glycoglycerolipiden, Glycoglycerolipiden und Glycosphingolipiden sowie deren Begleitstoffen mittels eines wässrigen Extraktionsverfahrens. Die lipoide Phase wird mit einer wässrigen Phase versetzt, die Anionen eines Salzes enthäl, welches in Wasser bei 20[deg.]C eine Löslichkeit von mindestens 30 g/L besitzt und bei der Dissoziation in Wasser Carbonat, Hydrogencarbonat, Metasilicat, Orthosilicat, Disilicat, Trisilicat, Acetat, Borat oder Tartrat bildet. Eine Vorrichtung zur Durchführung des Verfahrens wird auch beansprucht, wobei die Vorrichtung einen Intensivmischer zur Aufnahme der lipoiden Phase, eine Kavität mit Zuleitung zum Intensivmischer zur Aufnahme einer wässrigen Phase sowie eine Zentrifuge mit Zuleitung zum Intensivmischer umfasst.

  本发明涉及一种从类脂相中温和、无水解地分离甘油三酯以及甘油磷脂和甘油磷脂的设备和工艺、该工艺包含甘油三酯和酰基甘油酯或甘油三酯和糖磷脂和酰基甘油酯，同时通过水萃取工艺有效去除类脂相中的甘油三酯、甘油三酯和糖磷脂及其伴随物质。类脂相与含有阴离子盐的水相混合，阴离子盐在 20 摄氏度的水中溶解度至少为 30 克/升，在水中离解时形成碳酸盐、碳酸氢盐、偏硅酸盐、正硅酸盐、二硅酸盐、三硅酸盐、醋酸盐、硼酸盐或酒石酸盐。还要求提供一种用于实施该工艺的装置，其中该装置包括一个用于接收类脂相的强化混合器、一个带有通向强化混合器的进料管路用于接收水相的空腔和一个带有通向强化混合器的进料管路的离心机。
• DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION
  申请人：Dietz, Ulrich

  公开号：EP3042718A1

  公开（公告）日：2016-07-13

  The present invention is directed to a device for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the herein disclosed method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the use of the separation methods for carboxylic acids as discloses herein can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及一种从油、脂肪、水乳液、水介质和有机溶液中增溶和去除羧酸，特别是脂肪酸的装置。通过制备羧酸（尤其是脂肪酸）和至少含有一个脒基和/或胍基的增溶化合物的水性微乳液或纳米乳液，利用本文公开的方法制备的设备可分别用于从油、脂肪、水性乳液、亲油介质或有机溶液中分离羧酸。增溶化合物的增溶作用与本文公开的羧酸分离方法相结合，可用于治疗需要从血液中去除脂肪酸或分析羧酸的人，或处理食品、制药、化学、生物燃料工业或其他工业加工中的其他溶液。