6-methoxyindan-1-carboxylic acid chloride | 108048-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 6-methoxyindan-1-carboxylic acid chloride
• 英文别名: 6-methoxy-indane-1-carboxylic acid chloride；6-methoxy-2,3-dihydro-1H-indene-1-carbonyl chloride
• CAS: 108048-43-7
• 化学式: C₁₁H₁₁ClO₂
• 分子量: 210.66
• InChiKey: NXMNXEWKCSTFGE-UHFFFAOYSA-N

物化性质

• 沸点：
  301.1±42.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxyindan-1-carboxylic acid chloride 在 氨 作用下， 生成 6-methoxyindan-1-carboxamide
  参考文献：
  名称：

  Ray; Lahiri, Journal of the Indian Chemical Society, 1990, vol. 67, # 4, p. 324 - 326

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲氧基茚烷-1-羧酸 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 6-methoxyindan-1-carboxylic acid chloride
  参考文献：
  名称：

  1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the .alpha.2-adrenoceptor and the 5-HT1A receptor

  摘要：

  A number of 1,9-alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines were prepared and evaluated for 5-HT1A receptor and alpha 2-adrenoceptor affinity by using radioligand receptor binding techniques. Several compounds displayed 5-HT1A receptor affinity comparable to, or greater than, the known 5-HT1A ligand buspirone. The highest affinity 5-HT1A receptor ligands were N-alkyl-, N-allyl-5-chloro-, and 5-methoxy-1,2,3,4,8,9,10,10a-octahydronaphth[1,8-cd]azapines (4c, 4m, 4n), which had pKi values of 7.9-8.1. The S enantiomer of 4c had a higher affinity for the 5-HT1A receptor than the corresponding R isomer (pKi of 8.2 for (S)-4c vs 7.7 for (R)-4c). These compounds had a relatively low affinity for the alpha 2-adrenoceptor (pKi of 7 or less). On the other hand, the closely related 5-chloro-2-methyl-2,3,4,8,9,9a-hexahydro-1H-indeno[1,7-cd]azepine (3b) had high affinity for both the alpha 2-adrenoceptor (pKi = 8.1) and 5-HT1A receptor (pKi = 7.6). These results indicate that the two receptors may share common recognition sites.

  DOI：

  10.1021/jm00164a026

文献信息

• 1,9-alkano-bridged-2,3,4,5-tetrahydro-1H-3-benzazepines
  申请人：Syntex (U.S.A.) Inc.

  公开号：US04957914A1

  公开（公告）日：1990-09-18

  1,9-Alkano-bridged-2,3,4,5-tetrahydro-1H-3-benzazepines and the derivatives thereof, i.e., the compounds of Formula I: ##STR1## wherein: R is selected from the group consisting of: hydrogen, cyano, lower alkyl, lower alkenyl, and aralkyl; each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of: hydrogen, hydroxy, halo, trifluoromethyl, nitro, amido, lower alkoxy, lower alkyl, and lower alkylthio; and Y is lower alkylene having from two to four carbon atoms; and the pharmaceutically acceptable salts thereof, are useful as CNS agents, e.g., as antidepressants, anxiolytics and antihypertensives, and/or as precursors thereto.

  1,9-烷基桥联的2,3,4,5-四氢-1H-3-苯并氮平及其衍生物，即化合物I的化合物：##STR1##其中：R选自以下组：氢，氰基，较低的烷基，较低的烯基和芳基烷基；每个R1、R2和R3分别独立地选自以下组：氢，羟基，卤素，三氟甲基，硝基，酰胺基，较低的烷氧基，较低的烷基和较低的烷基硫基；Y为具有2至4个碳原子的较低烷基，以及其药学上可接受的盐，可用作中枢神经系统药物，例如抗抑郁剂，抗焦虑剂和降压剂，和/或其前体。
• CLARK, ROBIN D.;BERGER, JACOB;WEINHARDT, KLAUS K.
  作者：CLARK, ROBIN D.、BERGER, JACOB、WEINHARDT, KLAUS K.

  DOI：——

  日期：——
• 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene
  申请人：H. LUNDBECK A/S

  公开号：EP0281261B1

  公开（公告）日：1992-05-06
• US4847254A
  申请人：——

  公开号：US4847254A

  公开（公告）日：1989-07-11
• US4957914A
  申请人：——

  公开号：US4957914A

  公开（公告）日：1990-09-18