2,3-dihydroxy-6-hydroxymethyl-pyran-4-one | 2281-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2,3-dihydroxy-6-hydroxymethyl-pyran-4-one
• 英文别名: 2,3-Dihydroxy-6-hydroxymethyl-pyran-4-on；2,3-dihydroxy-6-(hydroxymethyl)pyran-4-one
• CAS: 2281-29-0
• 化学式: C₆H₆O₅
• 分子量: 158.111
• InChiKey: YGJDGLQXLXTELP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 barium dihydroxide 作用下， 生成 2,3-dihydroxy-6-hydroxymethyl-pyran-4-one
  参考文献：
  名称：

  Yabuta, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan, 1916, vol. 37, p. 1185

  摘要：

  DOI：

文献信息

• Endermic preparation of external application
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0422466A1

  公开（公告）日：1991-04-17

  Disclosed is an endermic preparation for external application which contains 5-hydroxymaltol or 3-­hydroxykojic acid as a skin-whitening or melanogenesis-­inhibiting component along with a cosmetic base. The preparation is applied to the human skin to display a noticeable skin-whitening and melanogenesis-inhibiting activity.

  本发明公开了一种用于外用的皮肤内用制剂，它含有作为美白或黑色素生成抑制成分的 5-hydroxymaltol 或 3-hydroxykojic acid 以及一种化妆品基质。将该制剂涂抹在人体皮肤上，可显示出明显的皮肤美白和黑色素生成抑制活性。
• Hydroxy-kojic acid skin peel
  申请人：——

  公开号：US20020082293A1

  公开（公告）日：2002-06-27

  The subject of the present invention is a hydroxy-kojic acid skin peel.

  本发明的主题是一种羟基曲酸换肤剂。
• Skin cream composition
  申请人：——

  公开号：US20040043963A1

  公开（公告）日：2004-03-04

  The present invention is related to compositions containing chitosan conjugated CLA (conjugated linoleic acid) and a chitosan conjugated Vitamin A or a &bgr;-cyclodextrin conjugated vitamin A. The invention also concerns the preparation of the compositions. The compositions according to the invention can be used as topical and cosmetic compositions as well as pharmaceutical compositions for treatment of atopical dermatitis, psoriasis eczema as well as eczema of different origins and solar dermatitis.

  本发明涉及含有壳聚糖共轭CLA（共轭亚油酸）和壳聚糖共轭维生素A或&bgr;-环糊精共轭维生素A的组合物。根据本发明的组合物可用作局部和化妆品组合物以及药物组合物，用于治疗顶部皮炎、牛皮癣湿疹以及不同来源的湿疹和日光性皮炎。
• Permeation enhancing compositions for anticholinergic agents
  申请人：Grenier Arnaud

  公开号：US20050287194A1

  公开（公告）日：2005-12-29

  A transdermal or topical composition including anticholinergic agents, such as oxybutynin, a urea-containing compound and a carrier system. A method is disclosed for treating a subject for urinary incontinence while reducing the incidences of peak concentrations of drug and undesirable side effects.

  一种透皮或局部组合物，包括抗胆碱能药物（如奥昔布宁）、含脲化合物和载体系统。本发明公开了一种治疗尿失禁患者的方法，同时降低了药物峰值浓度和不良副作用的发生率。
• A SKIN CREAM COMPOSITION
  申请人：Ethics Cosmeceuticals AB

  公开号：EP1341517B1

  公开（公告）日：2006-09-06