Pt(2-adamantanamine)2Cl2 | 75862-18-9

• 分子结构分类: 有机化合物
• 英文名称: Pt(2-adamantanamine)2Cl2
• 英文别名: adamplatin
• CAS: 75862-18-9；148812-03-7
• 化学式: C₂₀H₃₄Cl₂N₂Pt
• 分子量: 568.489
• InChiKey: NOKFOCYXPGSKCU-YAJVTDOOSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetraiodoplatinate 、 金刚烷胺 在 potassium iodide 、 silver nitrate 作用下， 以 水 、 丙酮 为溶剂， 反应 48.25h， 以63%的产率得到Pt(2-adamantanamine)2Cl2
  参考文献：
  名称：

  Targeted Polysaccharide Nanoparticle for Adamplatin Prodrug Delivery

  摘要：

  A series of conjugated hyaluronic acid particles (HAP), composed of a hydrophobic anticancer drug core and hydrophilic cyclodextrin/hyaluronic acid shell, were prepared through self-assembling and characterized by H-1 NMR titration, electron microscopy, zeta potential, and dynamic light-scattering experiments. The nanometersized HAP thus prepared was biocompatible and biodegradable and was well-recognized by the hyaluronic acid receptors overexpressed on the surface of cancer cells, which enabled us to exploit HAP as an efficient targeted delivery system for anticancer drugs. Indeed, HAP exhibited anticancer activities comparable to the commercial anticancer drug cisplatin but with lower side effects both in vitro and in vivo.

  DOI：

  10.1021/jm4014168

文献信息

• Rochon, Fernande D.; Doyon, Monique; Butler, Ian S., Inorganic Chemistry, 1993, vol. 32, # 12, p. 2717 - 2723
  作者：Rochon, Fernande D.、Doyon, Monique、Butler, Ian S.

  DOI：——

  日期：——