11-thioundecylphosphonic acid | 156125-36-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 11-thioundecylphosphonic acid
• 英文别名: 11-mercaptoundecylphosphonic acid；MPA；(11-Mercapto-undecanyl)-phosphonic acid；11-sulfanylundecylphosphonic acid
• CAS: 156125-36-9
• 化学式: C₁₁H₂₅O₃PS
• 分子量: 268.357
• InChiKey: VXLGFBKKMPMGST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-二叔丁基邻苯醌 、 11-thioundecylphosphonic acid 以 乙醇 为溶剂， 以37%的产率得到(11-((4,6-di-tert-butyl-2,3-dihydroxyphenyl)thio)undecyl)phosphonic acid
  参考文献：
  名称：

  具有生理活性片段的邻苯二酚硫醚：电化学，抗氧化剂和防冻活性。

  摘要：

  合成了许多基于3,5-二叔丁基邻苯二酚的不对称硫醚，这些硫原子在芳香环的第六位具有生理活性基团，并已进行了化学性质，抗氧化剂，防冻活性的评估。循环伏安法用于估算乙腈中硫醚的氧化电位。在第一阶段化合物的电氧化导致邻苯醌的形成。使用2,2'-二苯基-1-吡啶并肼基自由基（DPPH）测定化合物的抗氧化活性，对DNA进行氧化损伤实验，2,2'-偶氮双（2-ami基丙烷盐酸盐）的反应（ AAPH）诱导的谷胱甘肽耗竭（GSH），即大鼠肝脏脂质过氧化过程（Wistar）的匀浆，和铁（II）螯合测试。在所有测定中，化合物1-9具有比3,5-二叔丁基邻苯二酚（CatH2）更大的抗氧化效果。硫原子上生理活性基团的变化允许调节化合物的亲脂性和抗氧化活性。硫醚3、4和7证明了自由基清除，抗氧化活性和铁（II）结合性能的结合。研究了化合物1-9作为俄罗斯st鱼精子冷冻保存培养基的可能的冷冻保护剂。低温中的新型低温保

  DOI：

  10.1016/j.bioorg.2019.103003
• 作为产物：
  描述：

  11-溴-1-十一醇 在 氢氧化钾 、 氢溴酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 69.5h， 生成 11-thioundecylphosphonic acid
  参考文献：
  名称：

  Detection of Discrete Interactions upon Rupture of Au Microcontacts to Self-Assembled Monolayers Terminated with −S(CO)CH₃ or −SH

  摘要：

  Pulloff forces were measured under solvent for Au-coated atomic force microscopy (AFM) tips in contact with -S-acetate-, -O-acetale-, -SH-, or -OH-terminated self-assembled monolayers (SAMs). The SAMs were formed by adsorption of omega -functionalized undecylphosphonic acids on metal oxide substrates. In ethanol and hexadecane, the mean force required to rupture Au/S-acetate microcontacts was 7 times greater than the mean force required to break Au/O-acetate contacts, consistent with the known affinity of S-containing functional groups for Au. Further, rupture force histograms for Au/S-acetate microcontacts under ethanol or hexadecane showed 0.1 nN periodicity. Rupture forces for Au/-SH microcontacts were 4 times greater than for Au/-OH microcontacts under ethanol, and the rupture force histograms showed the same 0.1 nN periodicity. We have assigned this 0.1 nN force quantum to rupture of individual chemical bonds and have estimated the bond energy to be on the order of 10 kJ/mol. The specific interaction corresponding to this energy appears to be abstraction of Au atoms from the tip surface upon pulloff. Our ability to detect these discrete interactions was a function of the solvent in which the measurements were made. For example, in water there was no difference in the mean pulloff force for Au'S-acetate and Au/O-acetate contacts and the histograms did not exhibit periodicity. In general, mean rupture forces for tip-SAM microcontacts are strongly solvent-dependent. To observe single bond rupture forces directly, we argue that the tip-substrate interfacial energy must be negative and larger in absolute value than the substrate-solvent and tip-solvent interfacial energies [i.e., \gamma (substrate-tip)\ > (gamma (tip-solvent) + gamma (substrate-solvent))] Otherwise, nonspecific solvent exclusion effects dominate the microcontact adhesion. These measurements show that, whereas rupture fords for tip-SAM microcontacts are solvent-dependent, these forces can be sensitive, under the right conditions, to fluctuations in the number of discrete chemical interactions.

  DOI：

  10.1021/ja994524e

文献信息

• Method for producing optically active chrysanthemic acid
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20020123645A1

  公开（公告）日：2002-09-05

  Disclosed is a method for producing an optically active chrysanthemic acid, which method is characterized by optical resolution of a chrysanthemic acid having a trans isomer ratio of not less than 70% and an optical purity of 2% e.e. to less than 10% e.e. with an optically active organic.

  公开了一种生产光学活性菊酯酸的方法，该方法的特征是利用光学活性有机物对具有不低于70%的顺式异构体比率和2% e.e.至少10% e.e.的光学纯度的菊酯酸进行光学分辨。
• [EN] HETEROCYCLIC-DITHIOL CLICK CHEMISTRY<br/>[FR] CHIMIE CLICK DE DITHIOL HÉTÉROCYCLIQUE
  申请人：UNIV NORTHEASTERN

  公开号：WO2019014311A1

  公开（公告）日：2019-01-17

  Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.

  本发明涉及含有公式I中的基团的杂环交联聚合物、制备杂环交联聚合物的方法以及组合物，其中所述杂环通过与硫醇和硫醇酸盐进行交联。
• SYNTHESIS OF FUNCTIONALIZABLE OR FUNCTIONALIZED POLY(3,4-ETHYLENEDIOXYTHIPHENE)-BASED POLYMERS AND MONOMERS THEREFOR
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20200181163A1

  公开（公告）日：2020-06-11

  A method of forming a compound having the formula (I′): (I′) includes the reaction: (II′) in the presence of a base, wherein X is a halo atom selected from the group consisting of Cl, Br and I.

  一种制备化合物(I')的方法：(I')的化合物包括反应：(II')在碱的存在下进行，其中X是从群组选择的卤原子，所述群组包括Cl、Br和I。
• PROCESS FOR PRODUCING LAYERED PRODUCT, LAYERED PRODUCT, PROCESS FOR PRODUCING LAYERED PRODUCT WITH DEVICE USING SAID LAYERED PRODUCT, AND LAYERED PRODUCT WITH DEVICE
  申请人：Toyobo Co., Ltd.

  公开号：EP2865523A1

  公开（公告）日：2015-04-29

  There is provided a polyimide layered product with a support which has a smooth surface to enable a sophisticated device to be formed thereon and in which the layered polyimide does not peel off even in a high-temperature process on device formation, and furthermore, the polyimide layered product can be peeled off easily from the support after the device is formed on the polyimide layered product. By preparing a polyimide film with a face at the support side and subjected to a surface treatment; subjecting at least one of a face of the support and the face of the polyimide film which are opposite to each other to a patterning treatment using a coupling agent to form a satisfactorily bondable part and an easily releasable part which differ in adhesion/peel strength; subsequently, superposing the support and the polyimide film to be subjected to a pressurizing/heating treatment and to be bonded to each other; subjecting the surface of the polyimide film to an organic alkali treatment; and then, applying a polyamic acid solution free from a slip agent ingredient, drying the coating film and imidizing the film, a layered product having a structure of at least three layers in which at least one layer contains a slip agent material and both surface layers have no slip agent material is produced.

  本发明提供了一种具有支撑面的聚酰亚胺分层产品，该支撑面表面光滑，可在其上形成精密装置，而且即使在装置形成的高温过程中，分层聚酰亚胺也不会剥落，此外，在聚酰亚胺分层产品上形成装置后，聚酰亚胺分层产品可以很容易地从支撑面上剥落。通过制备表面位于支撑面的聚酰亚胺薄膜并对其进行表面处理；使用偶联剂对支撑面和聚酰亚胺薄膜相对面中的至少一个面进行图案化处理，以形成粘合力/剥离强度不同的可粘合部分和易剥离部分；然后，将支撑面和聚酰亚胺薄膜叠加在一起，进行加压/加热处理并相互粘合；将聚酰亚胺薄膜的表面进行有机碱处理；然后，涂上不含防滑剂成分的聚酰胺酸溶液，干燥涂膜并使薄膜酰亚胺化，这样就制成了一种具有至少三层结构的分层产品，其中至少一层含有防滑剂材料，而两层表面均不含防滑剂材料。
• DISPERSION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3305853A1

  公开（公告）日：2018-04-11

  A dispersion which contains a dispersant and particles selected from among metal particles and metal oxide particles, and which is characterized in that: the dispersant has a chemical structure that is able to be bonded or adsorbed to the particles; and the dispersant contains a low-molecular-weight dispersant that has at least one peak within a molecular weight region of 31 or more but less than 1,000 in the molecular weight distribution curve in terms of polyethylene glycol as determined by gel permeation chromatography and a high-molecular-weight dispersant that has at least one peak within a molecular weight region of 1,000 or more but 40,000 or less in the above-described molecular weight distribution curve.

  一种分散剂，它含有一种分散剂和选自金属颗粒和金属氧化物颗粒的颗粒，其特征在于分散剂的化学结构能与颗粒结合或吸附；分散剂含有一种低分子量分散剂，该分散剂在凝胶渗透色谱法测定的聚乙二醇分子量分布曲线中，至少有一个峰值在 31 或以上但小于 1,000 的分子量区域内；还含有一种高分子量分散剂，该分散剂在上述分子量分布曲线中，至少有一个峰值在 1,000 或以上但小于 40,000 的分子量区域内。