| 32083-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 32083-02-6
• 化学式: C₁₄H₁₇NO₅
• 分子量: 279.293
• InChiKey: TXSWVHWUPWTNRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.91
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 硫酸 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 14.0h， 生成 ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetate
  参考文献：
  名称：

  4-hydroxy-2-quinolones. 179*. Synthesis, structure, and anti-inflammatory activity of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid and its derivatives

  摘要：

  The synthesis of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid has been carried out and the structure and acid properties studied. Preparative methods for its esterification and amidation are proposed. The anti-inflammatory properties of the synthesized compounds have been evaluated.

  DOI：

  10.1007/s10593-010-0607-x
• 作为产物：
  描述：

  邻甲氨基苯甲酸甲酯 、 丁二酸单甲酯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  4-hydroxy-2-quinolones. 179*. Synthesis, structure, and anti-inflammatory activity of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid and its derivatives

  摘要：

  The synthesis of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid has been carried out and the structure and acid properties studied. Preparative methods for its esterification and amidation are proposed. The anti-inflammatory properties of the synthesized compounds have been evaluated.

  DOI：

  10.1007/s10593-010-0607-x