tripropylene glycol bis-mesylate | 1167572-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: tripropylene glycol bis-mesylate
• 英文别名: 3-[3-(3-Methylsulfonyloxypropoxy)propoxy]propyl methanesulfonate
• CAS: 1167572-55-5
• 化学式: C₁₁H₂₄O₈S₂
• 分子量: 348.439
• InChiKey: NEDNKHDWZBOSEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-碘苯酚 、 tripropylene glycol bis-mesylate 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 20.0h， 以79%的产率得到1,3-bis(3-(4-iodophenoxy)propoxy)propane
  参考文献：
  名称：

  Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

  摘要：

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.016
• 作为产物：
  描述：

  4,8-二氧杂十一烷-1,11-二醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到tripropylene glycol bis-mesylate
  参考文献：
  名称：

  Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

  摘要：

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.016

文献信息

• [EN] MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE<br/>[FR] MODULATEURS DE PROTÉOLYSE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：ARVINAS INC

  公开号：WO2018226542A1

  公开（公告）日：2018-12-13

  The present disclosure relates to bifunctional compounds, which find utility as modulators of c-Met and/or p38 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为c-Met和/或p38（靶蛋白）的调节剂具有实用性。具体而言，本公开是针对包含一端结合到相应E3泛素连接酶的Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源物2配体的双功能化合物，另一端结合到靶蛋白的部分，使得靶蛋白与泛素连接酶靠近以实现靶蛋白的降解（和抑制）。本公开展示了与靶蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由靶蛋白聚集或积累导致的疾病或紊乱。
• LINEAR AMINE FUNCTIONALIZED POLY(TRIMETHYLENE ETHER) COMPOSITIONS
  申请人：QI KAI

  公开号：US20100160573A1

  公开（公告）日：2010-06-24

  The present invention relates to linear amine-functionalized poly(trimethylene ether) compositions, and processes to produce these compositions.
• US7728175B1
  申请人：——

  公开号：US7728175B1

  公开（公告）日：2010-06-01
• US7919656B2
  申请人：——

  公开号：US7919656B2

  公开（公告）日：2011-04-05
• Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities
  作者：Andrew L. LaFrate、Kathryn E. Carlson、John A. Katzenellenbogen

  DOI：10.1016/j.bmc.2009.04.016

  日期：2009.5

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.