4-氯苯二氮杂六氟磷酸盐 | 1582-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氯苯二氮杂六氟磷酸盐
• 中文别名: 一缩二乙二醇一(2-乙基已基)醚；一缩二乙二醇一异辛醚；二乙二醇单辛醚；异辛基卡必醇；二甘醇异辛醚；2-{(2-[(2-乙基己基)氧基]乙氧基}乙醇；氟乐灵；二乙二醇一(2-乙基已基)醚；二乙二醇(2-乙基已基)醚；二乙二醇单(2-乙基已基)醚；一缩二乙二醇单(2-乙基已基)醚；二甘醇一异辛醚；二甘醇单(2-乙己基)醚；二甘醇(2-乙己基)醚；2-乙己基卡必醇；4-氯重氮苯六氟磷酸盐；一缩二乙二醇单异辛醚；二甘醇一(2-乙己基)醚
• 英文名称: 4-Chlorobenzenediazonium hexafluorophosphate
• 英文别名: 4-chlorobenzenediazonium;hexafluorophosphate
• CAS: 1582-27-0
• 化学式: C6H4ClF6N2P
• 分子量: 284.52
• InChiKey: JOLVAGIWTVZCNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.21
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• 危险等级：
  8
• 危险品标志：
  C
• 危险类别码：
  R36/37/38
• 危险品运输编号：
  UN 1759
• 包装等级：
  III
• 危险类别：
  8
• 安全说明：
  S24/25

SDS

Name:	4-Chlorobenzenediazonium hexafluoro- phosphate Material Safety Data Sheet
Synonym:	None
CAS:	1582-27-0

Section 1 - Chemical Product MSDS Name:4-Chlorobenzenediazonium hexafluoro- phosphate Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1582-27-0	4-Chlorobenzenediazonium hexafluoro- p	ca.100	216-429-3

Hazard Symbols: C
Risk Phrases: 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage. May cause chemical conjunctivitis.
Skin:
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not ingest or inhale. Use with adequate ventilation. Wash clothing before reuse. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20C).

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1582-27-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: tan
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H4ClF6N2P
Molecular Weight: 284.52

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
None reported.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1582-27-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Chlorobenzenediazonium hexafluoro- phosphate - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION
Other No information available.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, N.O.S.*
Hazard Class: 8
UN Number: 1759
Packing Group: II
IMO
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing Group: II
RID/ADR
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing group: II

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1582-27-0: No information available.
Canada
CAS# 1582-27-0 is listed on Canada's NDSL List.
CAS# 1582-27-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1582-27-0 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-Amino-4-chloro-6-neopentylpyrimidine 、 sodium acetate 、 溶剂黄146 、 4-氯苯二氮杂六氟磷酸盐 在 锌 作用下， 以 水 、 water ethanol 为溶剂， 反应 13.0h， 以gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid的产率得到4-Chloro-2,5-diamino-6-neopentyl-pyrimidine
  参考文献：
  名称：

  Novel purine inhibitors of fructose-1,6-bisphosphatase

  摘要：

  化合物1的新型嘌呤类化合物，其药物可接受的前药和盐，以及它们作为果糖1,6-二磷酸酶抑制剂的用途。

  公开号：

  US20050277619A1

文献信息

• Purine inhibitors of fructose 1,6-bisphosphatase
  申请人：Metabasis Therapeutics, Inc.

  公开号：US06284748B1

  公开（公告）日：2001-09-04

  Novel purine compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described. wherein A is selected from the group consisting of —NR82, —NHSO2R3, —OR5, —SR5, halo, lower alkyl, —CON(R4)2, guanidino, amidino, —H, and perhaloalkyl; E is selected from the group consisting of —H, halo, lower alkylthio, lower perhaloalkyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, —CN, and —NR72; X is selected from the group consisting of -alk-NR—, alkylene, alkenylene, alkynylene, arylene, heteroarylene, -alk-NR-alk-, -alk-O-alk-, -alk-S-alk-, -alk-S—, alicyclicene, heteroalicyclicene, 1,1-dihaloalkylene, —C(O)-alk-, —NR—C(O)—NR′—, -alk-NR—C(O)—, -alk-C(O)—NR—, —Ar-alk-, and -alk-Ar—, all optionally substituted, wherein each R and R′ is independently selected from —H and lower alkyl, and wherein each “alk” and “Ar” is an independently selected alkylene or arylene, respectively; Y is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, aryl, alicyclic, heteroalicyclic, aralkyl, aryloxyalkyl, alkoxyalkyl, —C(O)R3, —S(O)2R3, —C(O)—OR3, —CONHR3, —NR22, and —OR3, all except H are optionally substituted; and pharmaceutically acceptable prodrugs and salts thereof.

  本文描述了以下结构的新型嘌呤化合物及其作为果糖-1,6-二磷酸酶抑制剂的用途。其中A选自以下组合物：—NR82、—NHSO2R3、—OR5、—SR5、卤素、低碳基、—CON（R4）2、鸟氨酸基、酰胺基、—H和全氟碳基；E选自以下组合物：—H、卤素、低硫代烷基、低全氟碳基、低碳基、低烯基、低炔基、低烷氧基、—CN和—NR72；X选自以下组合物：-烷基-NR-、亚烷基、烯基亚烷基、炔基亚烷基、芳基、杂芳基、-烷基-NR-烷基、-烷基-O-烷基、-烷基-S-烷基、-烷基-S-、脂环基、杂脂环基、1,1-二卤代烷基、—C（O）-烷基、—NR—C（O）—NR′—、-烷基-NR-C（O）—、-烷基-C（O）-NR-、—Ar-烷基、和-烷基-Ar-，所有这些都可以选择性地被取代，其中每个R和R′独立地选自—H和低碳基，并且每个“alk”和“Ar”分别是独立选择的烷基或芳基；Y选自以下组合物：—H、烷基、烯基、炔基、芳基、脂环、杂脂环、芳基烷基、芳氧基烷基、烷氧基烷基、—C（O）R3、—S（O）2R3、—C（O）—OR3、—CONHR3、—NR22和—OR3，除H外都可以选择性地被取代；以及其药物可接受的前药和盐。
• Purine inhibitors of fructose-1,6-bisphosphatase
  申请人：Metabasis Therapeutics, Inc.

  公开号：US07285543B2

  公开（公告）日：2007-10-23

  Novel purine compounds of Formula 1, pharmaceutically acceptable prodrugs and salts thereof, and their use as fructose 1,6-bisphosphatase inhibitors.

  1式新型嘌呤化合物，其药物可接受的前药和盐，以及它们作为果糖1,6-二磷酸酶抑制剂的用途。