2-Carboxy-4,5-dimethyl-tetrahydro-2H-pyran | 90113-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-Carboxy-4,5-dimethyl-tetrahydro-2H-pyran
• 英文别名: 4,5-Dimethyl-tetrahydropyrano-2-carbonsaeure；4,5-dimethyl-tetrahydro-pyran-2-carboxylic acid；4,5-Dimethyl-tetrahydro-pyran-2-carbonsaeure；4,5-Dimethyloxane-2-carboxylic acid
• CAS: 90113-70-5
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: KQPUKZCSGWUTIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 铂 作用下， 生成 2-Carboxy-4,5-dimethyl-tetrahydro-2H-pyran
  参考文献：
  名称：

  Achmatowicz; Zamojski, Croatica Chemica Acta, 1957, vol. 29, p. 269,272

  摘要：

  DOI：

文献信息

• PROCESS FOR THE PREPARATION OF HIGHLY O-SULFATED EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE AND INTERMEDIATES THEREIN
  申请人：ORESTE Pasqua Anna

  公开号：US20120253029A1

  公开（公告）日：2012-10-04

  A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.

  一种新方法被描述用于过度硫酸化epiK5-N-硫酸盐以获得具有非常高的硫酸化程度的epiK5-胺基-O-过度硫酸盐，通过随后的N-硫酸化，提供至少4个硫酸化程度的新的epiK5-N，O-过度硫酸盐衍生物，在凝血参数上基本上没有活性，并且在化妆品或制药领域中有用。还描述了新的低分子量epiK5-N-硫酸盐，可用作制备相应的LMW-epiK5-N，O-过度硫酸盐衍生物的中间体。
• EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE WITH A VERY HIGH DEGREE OF SULFATION
  申请人：Oreste Pasqua Anna

  公开号：US20110021766A1

  公开（公告）日：2011-01-27

  A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
• PROCESS FOR THE PREPARATION OF HIGHLY O-SULFATED, EPIMERIZED DERIVATIVES OF K5 POLYSACCHRIDE AND INTERMEDIATES THEREIN
  申请人：GLYCORES 2000 S.R.L.

  公开号：US20140316129A1

  公开（公告）日：2014-10-23

  A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
• US8193166B2
  申请人：——

  公开号：US8193166B2

  公开（公告）日：2012-06-05
• US8513407B2
  申请人：——

  公开号：US8513407B2

  公开（公告）日：2013-08-20