4-Morpholino-4-oxo-buttersaeure-amid | 3510-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-Morpholino-4-oxo-buttersaeure-amid
• 英文别名: 4-morpholin-4-yl-4-oxo-butyramide；4-Morpholin-4-yl-4-oxobutanamide
• CAS: 3510-68-7
• 化学式: C₈H₁₄N₂O₃
• mdl: MFCD19314077
• 分子量: 186.211
• InChiKey: BTUUZJULMZEAGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1204652A1

  公开（公告）日：2002-05-15
• MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS
  申请人：Aventis Pharmaceuticals, Inc.

  公开号：EP1515726A1

  公开（公告）日：2005-03-23
• [EN] NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSES DE DERIVES DE SUCCINATE UTILISES COMME INHIBITEURS DES CYSTEINE PROTEASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2001009110A1

  公开（公告）日：2001-02-08

  Disclosed are novel succinate derivative compounds of formula (I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
• [EN] MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS<br/>[FR] DERIVES DE MORPHOLINE ET DE TETRAHYDROPYRANE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE CATHEPSINE
  申请人：AVENTIS PHARMA INC

  公开号：WO2004002491A1

  公开（公告）日：2004-01-08

  The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.