10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid (2-amino-ethyl)-amide | 866325-28-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid (2-amino-ethyl)-amide
• 英文别名: N-(2-aminoethyl)-4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carboxamide
• CAS: 866325-28-2
• 化学式: C₁₈H₂₁N₃O₃
• 分子量: 327.383
• InChiKey: PMEGHKSYWUTJHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  84.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid (2-amino-ethyl)-amide 、 3B-羟基-D5-胆烯酸 在 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Novel Compound and Functional Luminescent Probe Comprising the Same

  摘要：

  本发明涉及一种化合物，其特征在于包含一个连接体、一个与连接体的第一端连接的氧浓度响应性荧光团和一个与连接体的第二端连接的荧光团。在该化合物中，优选是荧光团的三重态能级低于荧光团。该化合物可用作氧响应性荧光探针。

  公开号：

  US20110201802A1
• 作为产物：
  描述：

  coumarin 343 acid chloride 在 C₆H₁₅NO₆S 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 48.0h， 生成 10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid (2-amino-ethyl)-amide
  参考文献：
  名称：

  基于杯芳烃的荧光比例温度探针†

  摘要：

  我们报告了第一个基于大环的比例式分子温度计，利用了用两个不同的荧光团官能化的杯芳烃的构象热敏性。由于温度依赖于有机荧光团之间的激发能传递效率，因此温度计可在60°C宽的温度范围内工作，灵敏度为4％C -1。

  DOI：

  10.1039/c9cc04577e

文献信息

• A FRET approach to phosgene detection
  作者：Hexiang Zhang、Dmitry M. Rudkevich

  DOI：10.1039/b614725a

  日期：——

  A FRET approach towards potential detection of phosgene is presented, which is based on a selective chemical reaction between phosgene (or triphosgene as a simulant) and donor and acceptor fluorophores.

  本研究提出了一种基于FRET的方法，用于潜在的光气检测，主要依赖于光气（或三光气作为模拟物）与供体和受体荧光团之间的选择性化学反应。
• Labeling reagent
  申请人：Heindl Dieter

  公开号：US20070196852A1

  公开（公告）日：2007-08-23

  The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.

  当前发明将取代的吲哚核苷作为标记寡核苷酸探针的末端和内部构建块，用于检测、分析和定量核酸。取代基包括一个连接基团和一个可检测基团或一个连接基团和一个反应基团，用于后合成耦合。这些修饰的核苷酸赋予了广泛的应用领域。这些新的取代吲哚核苷可以用作标记试剂，用于轻松制备优化的杂交探针、Taqman探针或分子信标探针。
• NOVEL COMPOUND AND FUNCTIONAL LUMINESCENT PROBE COMPRISING SAME
  申请人：National University Corporation Gunma University

  公开号：EP2348314A1

  公开（公告）日：2011-07-27

  Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe.

  本发明公开了一种化合物，其特征在于该化合物由连接体、与连接体的第一端相连的氧浓度响应型荧光团以及与连接体的第二端相连的荧光团组成。在该化合物中，荧光团的三重态水平最好低于荧光团的三重态水平。该化合物可用作氧响应型发光探针。
• Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna
  作者：Raymond P. Briñas、Thomas Troxler、Robin M. Hochstrasser、Sergei A. Vinogradov

  DOI：10.1021/ja052947c

  日期：2005.8.24

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.
• Methanesulfonylaminoindole derivatives and labeled oligonucleotide probes containing them
  申请人：Roche Diagnostics GmbH

  公开号：EP1842923B1

  公开（公告）日：2015-07-15