2-(3-bromo-propyl)-pyridine; hydrobromide | 90006-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-bromo-propyl)-pyridine; hydrobromide
• 英文别名: 2-(3-Brom-propyl)-pyridin; Hydrobromid；3-pyridinylpropylbromide, hydrobromide；3-pyridinylpropylbromide hydrobromide；3-Pyridinylpropyl bromide hydrobromide；2-(3-bromopropyl)pyridine;hydrobromide
• CAS: 90006-15-8
• 化学式: BrH*C₈H₁₀BrN
• 分子量: 280.99
• InChiKey: NEVQFGFZDVFQJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.99
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-bromo-propyl)-pyridine; hydrobromide 在 potassium carbonate 作用下， 生成 2,3-dihydro-1H-indolizinium; bromide
  参考文献：
  名称：

  Eine Synthese des δ-Coniceins

  摘要：

  DOI：

  10.1002/ardp.19512840509
• 作为产物：
  描述：

  2-吡啶丙醇 在 氢溴酸 、 溶剂黄146 作用下， 生成 2-(3-bromo-propyl)-pyridine; hydrobromide
  参考文献：
  名称：

  Eine Synthese des δ-Coniceins

  摘要：

  DOI：

  10.1002/ardp.19512840509

文献信息

• Polycyclicamine with psychotropic activity
  申请人：American Home Products Corporation

  公开号：US04855430A1

  公开（公告）日：1989-08-08

  There are disclosed compounds of the formula ##STR1## wherein R represents ##STR2## where X is lower alkylene, vinylene or O; Y is lower alkylene or vinylene; the dotted line represents an optional double bond; m is 1-3; n is 2-4; A is phenyl, benzoyl, pyridinyl, quinolinyl or quinoxalinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl; or when m is>1, A represents the grouping ##STR3## where B is phenyl, pyrimidinyl, pyridinyl or pyrazinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl, with the proviso that where R is ##STR4## A is other than unsubstituted or substituted benzoyl or pyridinyl; and the pharmacologically acceptable salts thereof and their use as antipsychotic/anxiolytic and antidepressant agents and in the treatment of sexual dysfunction and having a low liability for extrapyramidal side effects.

  已公开的化合物的化学式为##STR1##其中R代表##STR2##其中X是较低的烷基、乙烯基或氧；Y是较低的烷基或乙烯基；虚线表示可选的双键；m为1-3；n为2-4；A为苯基、苯甲酰基、吡啶基、喹啉基或喹啉基，或者上述任何一种被较低烷基、较低烷氧基、卤素、氰基、硝基或三氟甲基取代；或当m＞1时，A代表上述取代为较低烷基、较低烷氧基、卤素、氰基、硝基或三氟甲基的苯基、嘧啶基、吡啶基或吡啄啉基的群；其中R为##STR4##时，A不是未取代或取代的苯甲酰基或吡啶基；以及它们的药理学上可接受的盐及其用作抗精神病/抗焦虑和抗抑郁药物以及治疗性功能障碍并且对外部副作用的责任较低。
• 2,3,4,9-tetrahydro-2-heteroarylalkyl-1H-pyrido(3,4-B)indoles having
  申请人：American Home Products Corporation

  公开号：US04719211A1

  公开（公告）日：1988-01-12

  This invention concerns tetrahydropyridoindoles of the formula: ##STR1## wherein Q represents ##STR2## in which R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or --COO(C.sub.1-2) alkyl, and n is an integer from 1 to 7; R.sub.1 is hydrogen, halogen, hydroxy, or C.sub.1-3 alkyl; and R.sub.2 is hydrogen, C.sub.1-4 alkyl or --(CH.sub.2).sub.m --A where A is --N(CH.sub.3).sub.2,--N(C.sub.2 H.sub.5).sub.2, ##STR3## in which Ar is 2-pyrimidinyl, 2-pyrazinyl, phenyl, or phenyl substituted by a methyl, ethyl, methoxy, ethoxy, or trifluoromethyl group; and m is an integer from 1-4, or physiologically acceptable salts thereof, providing however that when n is 1, Q may not be quinolinyl. These compounds exhibit antihypertensive properties. Four of the disclosed compounds also exhibit antipsychotic properties. Also disclosed are compounds of Formula XX in which Q of Formula I is replaced by Q.sub.1, wherein Q.sub.1 is 2- or 3-pyridinyl, and R.sub.2 of Formula I is restricted to hydrogen. The compounds of Formula XX exhibit antipsychotic properties.

  这项发明涉及公式为的四氢吡啶吲哚：其中Q代表其中R.sub.3为氢，C.sub.1-4烷基，C.sub.1-4烷氧基或--COO(C.sub.1-2)烷基，n为1到7的整数；R.sub.1为氢，卤素，羟基或C.sub.1-3烷基；R.sub.2为氢，C.sub.1-4烷基或--(CH.sub.2).sub.m --A，其中A为--N(CH.sub.3).sub.2，--N(C.sub.2 H.sub.5).sub.2，其中Ar为2-嘧啶基，2-吡啶基，苯基或被甲基，乙基，甲氧基，乙氧基或三氟甲基基取代的苯基；m为1-4的整数，或其生理上可接受的盐，但当n为1时，Q可能不是喹啉基。这些化合物具有降压作用。所述的四种化合物还具有抗精神病作用。还披露了公式为XX的化合物，其中公式I的Q被Q.sub.1取代，其中Q.sub.1为2-或3-吡啶基，公式I的R.sub.2限制为氢。公式XX的化合物具有抗精神病作用。
• Antipsychotic .gamma.-carbolines
  申请人：American Home Products Corporation

  公开号：US04636563A1

  公开（公告）日：1987-01-13

  The compounds: ##STR1## in which R.sup.1 is hydrogen, halogen, hydroxy, or alkyl; R.sup.2 is substituted or unsubstituted pyridinyl, pyrazinyl, quinolinyl or quinoxalinyl and said substituents are alkyl, alkoxy, alkoxycarbonyl, halogen, cyano or nitro; and n is 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof, are antipsychotic and anxiolytic agents.

  化合物：##STR1## 其中R.sup.1是氢，卤素，羟基或烷基; R.sup.2是取代或未取代的吡啶基，吡嗪基，喹啉基或喹喔啉基，所述取代基是烷基，烷氧基，烷氧羰基，卤素，氰基或硝基; n为2,3,4,5或6; 或其药学上可接受的盐，是抗精神病和抗焦虑药物。
• Gamma-carbolines
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0223344A1

  公开（公告）日：1987-05-27

  The compounds of formula in which R' is hydrogen, halogen, hydroxy, or alkyl; R2 is substituted or unsubstituted pyridinyl, pyrazinyl, quinolinyl or quinoxalinyl and said substituents are alkyl, alkoxy, alkoxycarbonyl, halogen, cyano or nitro; and n is 2, 3, 4, 5 or 6; and the pharmaceutically acceptable salt thereof, are antipsychotic and anxiolytic agents.

  式中的化合物 其中 R' 为氢、卤素、羟基或烷基；R2 为取代或未取代的吡啶基、吡嗪基、喹啉基或喹喔啉基，所述取代基为烷基、烷氧基、烷氧羰基、卤素、氰基或硝基；n 为 2、3、4、5 或 6；及其药学上可接受的盐是抗精神病药和抗焦虑药。
• POLYCYCLICAMINES WITH PSYCHOTROPIC ACTIVITY
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0348460A1

  公开（公告）日：1990-01-03