(+/-)acetimido-1,5-dimethyl-3,3-diphenylpyrrolidine | 87274-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)acetimido-1,5-dimethyl-3,3-diphenylpyrrolidine
• 英文别名: N-(1,5-dimethyl-3,3-diphenyl-pyrrolidin-2-yliden)-acetamide；N-(1,5-Dimethyl-3,3-diphenyl-pyrrolidin-2-yliden)-acetamid；(NZ)-N-(1,5-dimethyl-3,3-diphenylpyrrolidin-2-ylidene)acetamide
• CAS: 87274-98-4；102181-28-2
• 化学式: C₂₀H₂₂N₂O
• 分子量: 306.407
• InChiKey: FDYJTBBYSYWOGG-VZCXRCSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.67
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (+/-)acetimido-1,5-dimethyl-3,3-diphenylpyrrolidine 在 盐酸 作用下， 生成 (+/-)-1,5-dimethyl-3,3-diphenyl-2-pyrrolidone
  参考文献：
  名称：

  3,3-Diphenyl-3-cyanpropylisocyanat-(1), 3,3-Diphenyl-3-cyan-1-methylpropylisocyanat-(1) und deren Umwandlungsprodukte

  摘要：

  DOI：

  10.1007/bf00898784
• 作为产物：
  描述：

  4-isocyanato-2,2-diphenyl-valeronitrile 在 氢溴酸 、 溶剂黄146 、 苯 作用下， 生成 (+/-)acetimido-1,5-dimethyl-3,3-diphenylpyrrolidine
  参考文献：
  名称：

  3,3-Diphenyl-3-cyanpropylisocyanat-(1), 3,3-Diphenyl-3-cyan-1-methylpropylisocyanat-(1) und deren Umwandlungsprodukte

  摘要：

  DOI：

  10.1007/bf00898784

文献信息

• Synthesis and Anticonvulsant Screening of 3,3 -Diphenyl- 2 -pyrrolidone Derivatives
  作者：George A. Brine、Karl G. Boldt

  DOI：10.1002/jps.2600720627

  日期：1983.6

  synthesized and screened for anticonvulsant activity. The synthetic route involved a mono-N-demethylation of an intermediate N,N-dimethylaminonitrile with methyl chloroformate followed by cleavage of the carbamate group. Of the six derivatives, (+/-)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride was effective in protecting mice against maximal electroshock (MES) -induced seizures at a 30-mg/kg

  合成了6种3,3-二苯基-2-吡咯烷酮衍生物，并筛选了其抗惊厥活性。合成途径涉及中间体N，N-二甲基氨基腈与氯甲酸甲酯的单-N-去甲基化，然后将氨基甲酸酯基团裂解。在这六种衍生物中，（+/-）-2-亚氨基-1,5-二甲基-3,3-二苯基吡咯烷盐酸盐可有效保护小鼠免受最大电击（MES）诱发的癫痫发作（剂量为30 mg / kg） 。
• Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes
  作者：Marc Veckeneer、Koen Overdam、Jan Monzer、Karin Kobuch、Wilfried Marle、Henk Spekreijse、Jan Meurs

  DOI：10.1007/s004170100341

  日期：2001.9

  Background: To evaluate the ocular toxicity of trypan blue (TB) injected into the vitreous cavity of rabbit eyes. TB is a dye that could be useful for staining epiretinal membranes during vitrectomy surgery. Methods: Ten New Zealand White (NZW) rabbits underwent gas-compression vitrectomy. Rabbits were divided into three groups to receive injections of 0.1 ml basic salt solution, 0.1 ml of a 0.06% TB solution or 0.1 ml of a 0.2% TB solution. Ocular toxicity was assessed by slit-lamp biomicroscopy, ophthalmoscopy, electroretinography and histology. Results: Transient posterior capsule opacification was noted in all animals. No significant reductions in a-wave or b-wave amplitudes were found in any of the animals. Light and electron microscopic examination of the inferior retina in the 0.2% TB-treated eyes showed damaged photoreceptors and marked disorganization. Immunohistochemical staining for rhodopsin was strongly reduced in those sections and staining for proliferation with Ki-67 was positive. No histological abnormalities were found in the upper retina of the 0.2% TB-treated eyes or in any part of the retina of the 0.06% TB-treated or control eyes. No histological abnormalities were found in any of the anterior chamber angle specimens. Conclusions: Although no signs of toxicity were found after the prolonged presence of TB at a concentration of 0.06% in the vitreous cavity of rabbit eyes, marked damage occurred in the lower retina of 0.2% TB-treated eyes. The shortterm presence of TB at a concentration of 0.06% in the vitreous cavity is harmless to the rabbit eye but a higher concentration of TB could be unsafe.