Ferrocenyl(2,6-dimethoxyphenyl)methane | 223140-25-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Ferrocenyl(2,6-dimethoxyphenyl)methane
• 英文别名: (2,6-dimethoxyphenyl)methylferrocene；cyclopenta-1,3-diene;2-(cyclopenta-2,4-dien-1-ylmethyl)-1,3-dimethoxybenzene;iron(2+)
• CAS: 223140-25-8
• 化学式: C₁₉H₂₀FeO₂
• 分子量: 336.214
• InChiKey: UOHNZOWXVSNXFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Ferrocenyl(2,6-dimethoxyphenyl)carbenium perchlorate 在 2-propanol 、 HClO₄ 作用下， 以 异丙醇 为溶剂， 以89%的产率得到Ferrocenyl(2,6-dimethoxyphenyl)methane
  参考文献：
  名称：

  Stability and reactivity of ferrocenyl(2,4,6-trimethoxyphenyl)carbenium salts

  摘要：

  Ferrocenyl(phenyl)methanols, Fc-CH Phi OH [Fc = Fe(eta(5)-C5H5)(eta(5)-C5H4), Phi(a) = 2,4,6-(MeO)(3)C6H2 (1a); Phi(b) = 2,6-(MeO)(2)C6H3 (1b)], were prepared by the reactions of Fc-CHO with Phi Li. 1a reacted with only a slight excess of perchloric acid or tetrafluoroboric acid even in methanol and in 1 M HCl acid to give dark violet crystals of the carbenium salts, [Fc-CH Phi(a)]X [X = ClO4 (2a), BF4 (2a')]. 1b reacted with these acids in diethylether to give the carbenium salts, [Fc-CH Phi(b)]X [X = ClO4 (2b), BF4 (2b') (dark red-brown crystals)] in good yields. The pK(R+) values could be measured in HCl acid for 1a (3.0) and for 1b (1.6). 2a and 2b were labile in hot 2-propanol to give the reduced compounds, Fc-CH(2)Phi. 1a and 1b reacted with 1,3,5-trimethoxybenzene, Phi(a)H, in 2-methyl-2-propanol containing only a slight excess of HCl acid to give diphenyl(ferrocenyl)methanes, Fc-CH Phi(2)(a) and Fc-CH Phi(a)Phi(b), respectively. While 1a decomposed in neat 1,3-dimethoxybenzene, Phi(b)H, in the presence of acid, 1b reacted to give 2,4-dimethoxyphenyl(2,6-dimethoxyphenyl)ferrocenylmethane, Fc-CH Phi(b)Phi(d) [Phi(d) = 2,4-(MeO)(2)C6H3]. The H-1-NMR spectrum of 2a was temperature-dependent and indicated that the free rotations of both Fc and Phi(a) groups in 2a existed at r.t. but were frozen at -60 degrees C. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(98)00925-5