ethyl 2-(4-methylphenyl)-4-(2-nitrobenzyl)furo<3,2-b>pyrrole-5-carboxylate | 145161-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(4-methylphenyl)-4-(2-nitrobenzyl)furo<3,2-b>pyrrole-5-carboxylate
• 英文别名: Ethyl 2-(4-methylphenyl)-4-[(2-nitrophenyl)methyl]furo[3,2-b]pyrrole-5-carboxylate
• CAS: 145161-97-3
• 化学式: C₂₃H₂₀N₂O₅
• 分子量: 404.422
• InChiKey: XCDMIMQJRWADAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 2-(4-tolyl)-4H-furo<3,2-b>pyrrole-5-carboxylate 、 2-硝基苄溴 在 四丁基溴化铵 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 50.0h， 以89%的产率得到ethyl 2-(4-methylphenyl)-4-(2-nitrobenzyl)furo<3,2-b>pyrrole-5-carboxylate
  参考文献：
  名称：

  Condensed O-, N-heterocycles by the transformation of azidoacrylates

  摘要：

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

  DOI：

  10.1007/bf00812330

文献信息

• Condensed O-, N-heterocycles by the transformation of azidoacrylates
  作者：Alzbeta Krutosikova、Miloslava Dandarova、Jana Chylova、Daniel Vegh

  DOI：10.1007/bf00812330

  日期：——

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.