ethyl 2-(4-tolyl)-4H-furo<3,2-b>pyrrole-5-carboxylate | 86345-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡咯
• 英文名称: ethyl 2-(4-tolyl)-4H-furo<3,2-b>pyrrole-5-carboxylate
• 英文别名: Ethyl 2-(4-methylphenyl)-furo[3,2-b]pyrrole-5-carboxylate；ethyl 2-(4-methylphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylate
• CAS: 86345-38-2
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: ZBKXORVARMPYFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-(4-tolyl)-4H-furo<3,2-b>pyrrole-5-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以72%的产率得到2-(4-tolyl)-4H-furo<3,2-b>pyrrole-5-carboxylic acid
  参考文献：
  名称：

  Krutosikova, Alzbeta; Kovac, Jaroslav; Kralovicova, Eva, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 3, p. 772 - 777

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (Z)-2-azido-3-[5-(4-methylphenyl)furan-2-yl]prop-2-enoate 以93%的产率得到
  参考文献：
  名称：

  KUTOSIKOVA A.;KOVAC J.;KRALOVICOVA E., COLLECT. CZECH. CHEM. COMMUN., 1983, 48, NO 3, 772-777

  摘要：

  DOI：

文献信息

• Synthesis of N-Phenylsulfonyl Protected Furo[3,2-b]pyrroles
  作者：Vladimír Bobošík、Alžbeta Krutošíková

  DOI：10.1135/cccc19940499

  日期：——

  Protection of nitrogen atom of heterocyclic molecules, such as indole and pyrrole types, enables various reactions of these systems. N-Phenylsulfonyl derivatives, which have been widely used for this purpose, were prepared in the indole series by the reaction of N-sodium and N-lithium salts with benzenesulfonyl chloride. This method requires waterfree and oxygenfree conditions. On the other hand, the phase transfer catalysis conditions used in this work obviates these disadvantages. We therefore selected the latter method for the preparation of variously substituted 4-phenylsulfonylfuro[3,2-b]pyrroles (I - VII) and 1-phenylsulfonylbenzo[b]furo[3,2-b]pyrroles (VIII - IX).

  保护杂环分子中的氮原子，如吲哚和吡咯类，可以使这些系统发生各种反应。已广泛用于此目的的N-苯磺酰衍生物，通过N-钠和N-锂盐与苯磺酰氯反应制备吲哚系列中。该方法需要无水和无氧条件。另一方面，本研究中使用的相转移催化条件消除了这些缺点。因此，我们选择了后一种方法来制备不同取代的4-苯磺酰基呋喃[3,2-b]吡咯（I-VII）和1-苯磺酰基苯并[ b]呋喃[3,2-b]吡咯（VIII-IX）。
• FLUORESCENT COMPOUND AND LABELING AGENT COMPRISING THE SAME
  申请人：Keio University

  公开号：EP2022794B1

  公开（公告）日：2017-08-23
• Krutosikova, Alzbeta; Kovac, Jaroslav; Kralovicova, Eva, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 7, p. 1878 - 1884
  作者：Krutosikova, Alzbeta、Kovac, Jaroslav、Kralovicova, Eva

  DOI：——

  日期：——
• Kralovicova, Eva; Krutosikova, Alzbeta; Kovac, Jaroslav, Collection of Czechoslovak Chemical Communications, 1986, vol. 51, # 1, p. 106 - 111
  作者：Kralovicova, Eva、Krutosikova, Alzbeta、Kovac, Jaroslav、Dandarova, Miloslava

  DOI：——

  日期：——
• Condensed O-, N-heterocycles by the transformation of azidoacrylates
  作者：Alzbeta Krutosikova、Miloslava Dandarova、Jana Chylova、Daniel Vegh

  DOI：10.1007/bf00812330

  日期：——

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.