4U3J8T84HE | 1438432-50-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4U3J8T84HE
• 英文别名: (2S)-2-[[(4S)-4-carboxy-4-(19-carboxynonadecanoylamino)butanoyl]amino]pentanedioic acid
• CAS: 1438432-50-8
• 化学式: C₃₀H₅₂N₂O₁₀
• 分子量: 600.7
• InChiKey: FVPJSRIABOGDRM-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  42
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  207
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• [EN] SELECTIVE PYY COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS PYY SÉLECTIFS ET LEURS UTILISATIONS
  申请人：NOVO NORDISK AS

  公开号：WO2016124687A1

  公开（公告）日：2016-08-11

  The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and derivatives thereof with a modifying group attached to the position corresponding to position 10 of hPYY(1-36). The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

  该发明涉及PYY化合物，其氨基酸在与hPYY(1-36)的位置30对应的位置上被色氨酸及其衍生物取代，同时在与hPYY(1-36)的位置10对应的位置上附有修饰基团。该发明的化合物是选择性Y2受体激动剂。该发明还涉及包含这种PYY化合物和药用可接受辅料的制药组合物，以及PYY化合物的医药用途。
• Selective PYY compounds and uses thereof
  申请人：Novo Nordisk A/S

  公开号：US10005824B2

  公开（公告）日：2018-06-26

  The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives thereof. The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

  本发明涉及具有 7Lys、30Trp 和 31Leu 氨基酸修饰的PYY 化合物，此外还有 22Ile 和/或 28Tyr 及其衍生物。本发明的化合物是选择性 Y2 受体激动剂。本发明还涉及包含此类PYY化合物和药学上可接受的赋形剂的药物组合物，以及PYY化合物的医疗用途。
• POLYPEPTIDES
  申请人：Novo Nordisk A/S

  公开号：EP2718314A2

  公开（公告）日：2014-04-16
• SELECTIVE PYY COMPOUNDS AND USES THEREOF
  申请人：Novo Nordisk A/S

  公开号：EP3307768A1

  公开（公告）日：2018-04-18
• AMYLIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Novo Nordisk A/S

  公开号：US20140018286A1

  公开（公告）日：2014-01-16

  The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.