1-(3,4,5-Trimethoxybenzyl)-thioharnstoff | 34967-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(3,4,5-Trimethoxybenzyl)-thioharnstoff
• 英文别名: N-3,4,5-Trimethoxybenzylthioharnstoff；N-[(3,4,5-Trimethoxyphenyl)methyl]thiourea；(3,4,5-trimethoxyphenyl)methylthiourea
• CAS: 34967-11-8
• 化学式: C₁₁H₁₆N₂O₃S
• 分子量: 256.326
• InChiKey: KRILHGQZPMVOPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  97.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compounds and their use for reducing uric acid levels
  申请人：Acquist LLC

  公开号：US10688095B2

  公开（公告）日：2020-06-23

  Bifunctional barbiturate-derivative compounds that increase uric acid excretion and reduce uric acid production, and monofunctional barbiturate-derivative compounds that either increase uric acid excretion or reduce uric acid production are provided. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders associated with excess uric acid, and for maintaining normal uric acid levels in blood or serum, or the whole body, are also provided. Pharmaceutical compositions comprising the bifunctional and monofunctional compounds are also provided.

  提供了可增加尿酸排泄和减少尿酸生成的双官能团巴比妥酸衍生物化合物，以及可增加尿酸排泄或减少尿酸生成的单官能团巴比妥酸衍生物化合物。还提供了使用这些化合物降低血液或血清中尿酸水平、治疗与尿酸过量有关的疾病以及维持血液或血清或全身正常尿酸水平的方法。还提供了包含双官能和单官能化合物的药物组合物。
• COMPOUNDS AND THEIR USE FOR REDUCING URIC ACID LEVELS
  申请人：Acquist LLC

  公开号：EP3481819B1

  公开（公告）日：2022-06-01
• Compounds and Their Use for Reducing Uric Acid Levels
  申请人：Acquist LLC

  公开号：US20190117654A1

  公开（公告）日：2019-04-25

  Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders associated with excess uric acid, and for maintaining normal uric acid levels in blood or serum, or the whole body, are also provided. Pharmaceutical compositions comprising the bifunctional and monofunctional compounds are also provided.