11-(1-acetyl-4-piperidinylidene)-8-chloro-5,11-dihydro-[1]-benzothiepino[4,3-b]pyridine-6-oxide | 126570-43-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 11-(1-acetyl-4-piperidinylidene)-8-chloro-5,11-dihydro-[1]-benzothiepino[4,3-b]pyridine-6-oxide
• 英文别名: 1-[4-(8-chloro-6-oxo-5H-[1]benzothiepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
• CAS: 126570-43-2
• 化学式: C₂₀H₁₉ClN₂O₂S
• 分子量: 386.902
• InChiKey: IDZMYHFCFPVBDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
  申请人：SCHERING CORPORATION

  公开号：EP0341860A1

  公开（公告）日：1989-11-15

  Novel benzopyrido piperidine, piperidylidene and piperazine compounds of the generalized formula are disclosed as useful for the treatment of asthma, allergy and inflammation. Novel pharmaceutical compositions containing such compounds and processes for producing the compounds are also disclosed.

  通式为哌啶、亚哌啶和哌嗪的新型苯并吡啶化合物 公开了可用于治疗哮喘、过敏和炎症的新型苯并吡啶哌啶、亚哌啶和哌嗪化合物。此外，还公开了含有此类化合物的新型药物组合物以及生产此类化合物的工艺。
• NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE
  申请人：SCHERING CORPORATION

  公开号：EP0411048A1

  公开（公告）日：1991-02-06
• US5104876A
  申请人：——

  公开号：US5104876A

  公开（公告）日：1992-04-14
• [EN] NOVEL BENZOPYRIDO PIPERIDINE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND METHODS OF USE
  申请人：SCHERING CORPORATION

  公开号：WO1989010369A1

  公开（公告）日：1989-11-02

  (EN) Novel benzopyrido piperidine, piperidylidene and piperazine compounds of generalized formula (I) are disclosed as useful for the treatment of asthma, allergy and inflammation. Novel pharmaceutical compositions containing such compounds and processes for producing the compounds are also disclosed.(FR) On a mis au point de nouveaux composés de benzopyrido piperidine, piperidylidène et piperazine de la formule générale (I), utiles pour le traitement de l'asthme, d'allergies et d'inflammations. On a également mis au point de nouvelles compositions pharmaceutiques contenant lesdits composés ainsi que des procédés de production de ces derniers.