Ethyl 2-[2-[3-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propanoyl]hydrazinyl]pyridine-3-carboxylate | 292155-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Ethyl 2-[2-[3-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propanoyl]hydrazinyl]pyridine-3-carboxylate
• CAS: 292155-98-7
• 化学式: C₂₁H₃₂N₄O₅
• 分子量: 420.509
• InChiKey: MSYAVCYIUGVXKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[2-[3-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propanoyl]hydrazinyl]pyridine-3-carboxylate 在 4 A molecular sieve 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 22.0h， 以77%的产率得到Ethyl 3-[2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]ethyl]-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate
  参考文献：
  名称：

  Synthesis of triazolopyridines as conformationally constrained tertiary amides

  摘要：

  Amide derivatives of cyclic amines are common templates for biologically active chemical entities. To constrain the tertiary amide moiety of N-acylpiperidine-based GPIIb/IIIa antagonists for further structure-activity study, we have prepared new 1,2,4-triazolo[4,3-a]pyridines. The syntheses of two classes of triazolopyridines are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00632-8
• 作为产物：
  描述：

  2-氯烟酸乙酯 在 N-甲基吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 肼 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 19.0h， 生成 Ethyl 2-[2-[3-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propanoyl]hydrazinyl]pyridine-3-carboxylate
  参考文献：
  名称：

  Synthesis of triazolopyridines as conformationally constrained tertiary amides

  摘要：

  Amide derivatives of cyclic amines are common templates for biologically active chemical entities. To constrain the tertiary amide moiety of N-acylpiperidine-based GPIIb/IIIa antagonists for further structure-activity study, we have prepared new 1,2,4-triazolo[4,3-a]pyridines. The syntheses of two classes of triazolopyridines are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00632-8

文献信息

• Synthesis of triazolopyridines as conformationally constrained tertiary amides
  作者：Edward C. Lawson、Bruce E. Maryanoff、William J. Hoekstra

  DOI：10.1016/s0040-4039(00)00632-8

  日期：2000.6

  Amide derivatives of cyclic amines are common templates for biologically active chemical entities. To constrain the tertiary amide moiety of N-acylpiperidine-based GPIIb/IIIa antagonists for further structure-activity study, we have prepared new 1,2,4-triazolo[4,3-a]pyridines. The syntheses of two classes of triazolopyridines are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.