4-氰基-4-(2-甲氧基苯基)环己酮 | 58379-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-氰基-4-(2-甲氧基苯基)环己酮
• 英文名称: 4-methoxyphenyl-4-cyano-cyclohexanone
• 英文别名: 1-cyano-1-(2-methoxyphenyl)cyclohexan-4-one；1-(2-Methoxyphenyl)-4-oxocyclohexanecarbonitrile；1-(2-methoxyphenyl)-4-oxocyclohexane-1-carbonitrile
• CAS: 58379-06-9
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: OJEYROFCWOJHCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2926909090

文献信息

• [EN] SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS<br/>[FR] ISOQUINOLINES ET ISOQUINOLINONES SUBSTITUÉES UTILISÉES COMME INHIBITEURS DE RHO-KINASE
  申请人：SANOFI AVENTIS

  公开号：WO2009156100A1

  公开（公告）日：2009-12-30

  The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

  该发明涉及用于治疗和/或预防与Rho激酶和/或Rho激酶介导的肌球蛋白轻链磷酸酶磷酸化相关疾病的配方(I)的取代异喹啉和异喹啉酮，以及含有这种化合物的组合物。
• Cycloalkyl inhibitors of potassium channel function
  申请人：——

  公开号：US20040072880A1

  公开（公告）日：2004-04-15

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  新型环烷基化合物可用作钾通道功能抑制剂（特别是Kv1亚家族电压门控K+通道的抑制剂，特别是抑制与超快速激活延迟整流K+电流IKur相关的Kv1.5），使用这些化合物预防和治疗心律失常和IKur相关疾病的方法，以及含有这些化合物的制药组合物。
• CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION
  申请人：Lloyd John

  公开号：US20070142333A1

  公开（公告）日：2007-06-21

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  新型环烷基化合物可作为钾通道功能抑制剂使用（特别是钾离子电压门控K+通道的Kv1亚家族的抑制剂，特别是与超快速激活延迟整流K+电流IKur相关的Kv1.5抑制剂），使用这种化合物预防和治疗心律失常和IKur相关疾病的方法，以及含有这种化合物的药物组合物。
• SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS
  申请人：Plettenburg Oliver

  公开号：US20110190341A1

  公开（公告）日：2011-08-04

  The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

  本发明涉及公式（I）的取代异喹啉和异喹啉酮，用于治疗和/或预防与Rho激酶和/或Rho激酶介导的肌球蛋白轻链磷酸酶的磷酸化相关的疾病，以及含有这些化合物的组合物。
• Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them
  申请人：SCHERING CORPORATION

  公开号：EP0073849A1

  公开（公告）日：1983-03-16

  Novel phenyl-1,2,3,4,-tetrahydrocarbazoles are anti-depressants useful in the treatment of mental depression of either endogenous or reactive nature. Processes for their preparation and pharmaceutical compositions containing them are also disclosed.

  新型苯基-1,2,3,4,-四氢咔唑是一种抗抑郁剂，可用于治疗内源性或反应性精神抑郁症。 还公开了其制备工艺和含有它们的药物组合物。