N-benzyl-1-(2,6-difluorophenyl)methanimine oxide | 1421638-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-1-(2,6-difluorophenyl)methanimine oxide
• CAS: 1421638-07-4
• 化学式: C₁₄H₁₁F₂NO
• 分子量: 247.244
• InChiKey: LXOBMDZKAWBWBV-YVLHZVERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-benzyl-1-(2,6-difluorophenyl)methanimine oxide 在 溶剂黄146 、 1-butyl-3-methylimidazolium Tetrafluoroborate 、 锌 作用下， 反应 0.43h， 生成
  参考文献：
  名称：

  Chakraborty, Bhaskar; Samanta, Amalesh; Luitel, Govinda Prasad, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 10, p. 1342 - 1351

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氟苯甲醛 、 N-苄基羟胺 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 1.0h， 生成 N-benzyl-1-(2,6-difluorophenyl)methanimine oxide
  参考文献：
  名称：

  Chakraborty, Bhaskar; Samanta, Amalesh; Luitel, Govinda Prasad, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 10, p. 1342 - 1351

  摘要：

  DOI：

文献信息

• Mechanochemical synthesis and cycloaddition reactions of fluoro nitrone under solvent‐free conditions and potential antimicrobial activities of the cycloadducts
  作者：Bhaskar Chakraborty

  DOI：10.1002/jhet.3736

  日期：2019.12

  Synthesis and cycloaddition reactions of fluoro nitrone under solvent‐free conditions using ball‐milling technique have been reported. Significant change in rate and yields of the cycloadducts have been noticed compared with solvent‐free microwave‐induced reactions of fluoro nitrones. The present study reports synthesis of N‐benzyl fluoro nitrone and its cycloaddition reactions with maleimides and

  据报道，采用球磨技术在无溶剂条件下合成了氟代硝酮，并进行了环加成反应。与无溶剂微波诱导的氟硝酮反应相比，已发现环加合物的速率和收率有显着变化。本研究报告了在无溶剂条件下N-苄基氟硝酮的合成及其与马来酰亚胺和少量电子不足的炔烃的环加成反应。发现合成的氟代环加合物显示出潜在的抗菌活性。
• An efficient ecofriendly protocol for the synthesis of novel fluoro isoxazoline and isoxazolidines using N-benzyl fluoro nitrone via cycloaddition reactions
  作者：Bhaskar Chakraborty、Govinda Prasad Luitel

  DOI：10.1016/j.tetlet.2012.11.111

  日期：2013.2

  1-Butyl-3-methylimidazolium based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of N-benzyl fluoro nitrones derived in situ from aldehydes and benzylhydroxylamine, with electron deficient alkynes to afford enhanced rates and improved yields of isoxazolines while with enals exclusively endo isoxazolidines are obtained with high selectivity. Synthetic potentiality of the novel isoxazolines and nitrones has also been tested successfully. (C) 2012 Elsevier Ltd. All rights reserved.