α-phenyl-α-tert-butyloxyacetaldehyde | 145125-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-phenyl-α-tert-butyloxyacetaldehyde
• 英文别名: 2-tert.-Butoxy-2-phenyl-acetaldehyd；2-[(2-Methylpropan-2-yl)oxy]-2-phenylacetaldehyde
• CAS: 145125-20-8
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: IAMKDLWHTKGFMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-4-phenyl-1,3-dioxolane 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 19.0h， 生成 α-phenyl-α-tert-butyloxyacetaldehyde
  参考文献：
  名称：

  An Efficient Procedure for the Regioselective Monoprotection of 1,2-Diols

  摘要：

  Nucleophilic ring opening of isopropylidene ketals by trimethylaluminum is described. This reagent offers a new method for selective monoprotection of 1,2-diols. The regioselectivity of this reaction was studied with simple diols and with carbohydrates.

  DOI：

  10.1016/s0040-4020(01)86582-0

文献信息

• INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
  申请人：Chang Han-Ting

  公开号：US20090318492A1

  公开（公告）日：2009-12-24

  Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

  本发明揭示了吲哚及其相关化合物、组合物和方法。本发明的化合物可用作磷脂酶抑制剂。本发明的化合物和组合物可用于治疗与磷脂酶相关的疾病，如动物主体中与胰岛素、体重和/或胆固醇相关的疾病。
• POLYHYDROXYALKANOIC ACID HAVING VINYL, ESTER, CARBOXYL OR SULFONIC ACID GROUP AND PRODUCING METHOD THEREFOR
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1758948B1

  公开（公告）日：2009-05-13
• EP1774410B1
  申请人：——

  公开号：EP1774410B1

  公开（公告）日：2008-11-19
• An Efficient Procedure for the Regioselective Monoprotection of 1,2-Diols
  作者：Derek H.R. Barton、Jieping Zhu

  DOI：10.1016/s0040-4020(01)86582-0

  日期：1992.9

  Nucleophilic ring opening of isopropylidene ketals by trimethylaluminum is described. This reagent offers a new method for selective monoprotection of 1,2-diols. The regioselectivity of this reaction was studied with simple diols and with carbohydrates.